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Norvinisterone

Chemical compound

Chemical compound

| Drugs.com =

| elimination_half-life =

Norvinisterone, sold under the brand names Neoprogestin and Nor-Progestelea, is a progestin and androgen/anabolic steroid (AAS) medication which was used in Europe but is now no longer marketed. It is taken by mouth.

Norvinisterone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has androgenic activity.

Norvinisterone was synthesized in 1953. It is no longer available.

Medical uses

Norvinisterone was used in hormonal contraception to prevent pregnancy.

Pharmacology

Pharmacodynamics

Norvinisterone is a progestogen. It appears to be quite androgenic, with about one-third and one-fifth of the androgenic and anabolic activity, respectively, of nandrolone in animal bioassays. However, it has also been reported to have little anabolic activity.

Chemistry

Norvinisterone, also known as 17α-vinyl-19-nortestosterone or as 17α-vinylestr-4-en-17β-ol-3-one, is a synthetic estrane steroid and a derivative of testosterone and 19-nortestosterone. Analogues of norvinisterone include the progestin norgesterone and the AAS vinyltestosterone.

History

Norvinisterone was synthesized in 1953 and was studied in humans by 1960.

Society and culture

Generic names

Norvinisterone is the generic name of the drug and its . It is also known as vinylnortestosterone and is known by its developmental code name SC-4641.

Brand names

Norvinisterone was marketed under the brand names Neoprogestin and Nor-Progestelea by Syntex.

Availability

Norgesterone is no longer marketed and hence is no longer available in any country.

References

References

  1. (1989). "[[Merck Index]]". Merck & Co..
  2. (14 November 2014). "The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies". Springer.
  3. (21 December 2001). "Concise Dictionary of Biomedicine and Molecular Biology". CRC Press.
  4. (12 March 2013). "Chemikalien und Drogen Teil A: N-Q". Springer Berlin Heidelberg.
  5. (August 1967). "Relationship between the anesthetic and gestagenic action and estrous behavior-inducing activity of different progestins". Endocrinology.
  6. (May 1956). "The myotrophic and androgenic effects of 17-ethyl-19-nortestosterone and related compounds". Endocrinology.
  7. (August 1959). "Structure-activity relationships of anabolic steroids: role of the 19-methyl group". The Journal of Clinical Endocrinology and Metabolism.
  8. (March 1960). "[Clinical trial of a new luteoid: norvinisterone]". El Dia Medico.
  9. http://www.micromedexsolutions.com/micromedex2/{{Dead link. (April 2020)
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androgens estranes hepatotoxins hormonal-contraception progestogens vinyl-compounds
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