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Nkx2-2as

FieldValue
NameNK2 transcription factor related, locus 2 (Drosophila), antisense
Organismmouse
TaxID10090
SymbolNkx2-2as
EntrezGene100313531
RefSeqmRNANR_030769
Chromosome2
EntrezChromosomeNC_000068.6
GenLoc_start146987678
GenLoc_end147179556

Nkx2-2as (Nkx2-2 antisense) is a long non-coding RNA. It is located in the cytoplasm of the cell. Nkx2-2as is involved in Neural development. Overexpression of Nkx2-2as results in increased levels of expression of the homeobox gene Nkx2-2 and enhances induction of the differentiation of oligodendrocytes. Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes.

References

References

  1. (August 2008). "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochemical and Biophysical Research Communications.
  2. (2009). "Therapeutic Ribonucleic Acids in Brain Tumors". Springer.
  3. (February 2010). "Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation". BMC Neuroscience.
  4. (June 2010). "Long non-coding RNAs in nervous system function and disease". Brain Research.
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