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Neuromedin N

Field	Value
Name	Neuromedin N
HGNCid	8038
Symbol	NN
EntrezGene	4922
Chromosome	12
Arm	q
Band	21

Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects. Composed of the amino acid sequence Lys-Ile-Pro-Tyr-Ile-Leu, neuromedin N is homologous to neurotensin, both of whose sequences are found on the pro neurotensin/neuromedin N precursor C-terminus. Both sequences of neuromedin N as well as neurotensin are flanked by Lys-Arg amino acids, which comprise a consensus sequence for the endoprotease proprotein convertase. Neuromedin N is primarily synthesized in the neural and intestinal tissues of mammals; in studies performed in mice, neuromedin N's physiological effects were shown to include hypothermia and analgesia, arising from the peptide's ligand association to and interaction with neurotensin type 2 (NTS2) G protein-coupled receptors.

References

"Neuromedin N - Compound Summary". U.S. National Library of Medicine.
(1992). "Posttranslational processing of the neurotensin/neuromedin-N precursor". Annals of the New York Academy of Sciences.
(1992). "Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N". Annals of the New York Academy of Sciences.
(October 1995). "Neurotensin receptors: binding properties, transduction pathways, and structure". Cellular and Molecular Neurobiology.
(2001). "Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum". Neuroscience.
(February 2002). "Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity". Biochemical and Biophysical Research Communications.
(October 2006). "Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases". Peptides.
(June 2016). "Synthesis and binding characteristics of [(3)H]neuromedin N, a NTS2 receptor ligand". Neuropeptides.
(July 1984). "Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord". Biochemical and Biophysical Research Communications.
(June 1988). "Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors". European Journal of Pharmacology.

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