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Netilmicin

Chemical compound

Chemical compound

| Drugs.com =

| elimination_half-life = 2.5 hours

Netilmicin (1-N-ethylsisomicin) is a semisynthetic aminoglycoside antibiotic, and a derivative of sisomicin, produced by Micromonospora inyoensis. Aminoglycoside antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.

It was patented in 1973 and approved for medical use in 1981. It was approved for medical use in the UK in December 2019, for the treatment of external infections of the eye. It is on the World Health Organization's List of Essential Medicines. TOC

Comparison with drugs

According to the British National Formulary (BNF), netilmicin has similar activity to gentamicin, but less ototoxicity in those needing treatment for longer than 10 days. Netilmicin is active against a number of gentamicin-resistant Gram-negative bacteria but is less active against Pseudomonas aeruginosa than gentamicin or tobramycin.

References

References

  1. (18 November 2020). "Drug and medical device highlights 2019: Helping you maintain and improve your health".
  2. (2006). "Analogue-based Drug Discovery". John Wiley & Sons.
  3. (2 June 2020). "Netilmicin".
  4. (2021). "World Health Organization model list of essential medicines: 22nd list (2021)". World Health Organization.
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aminoglycoside-antibiotics micromonosporaceae
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