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Myxopyronin

Group of chemical compounds

Group of chemical compounds

Myxopyronins (Myx) are a group of alpha-pyrone antibiotics, which are inhibitors of bacterial RNA polymerase (RNAP).{{Citation

Myxopyronin was first isolated in 1983 from a soil bacterium by Werner Kohl and Herbert Irschik at the Helmholtz Centre for Infection Research (former GBF). A total synthesis of myxopyronin was first reported in 1998 by James S. Panek and co-workers.{{Citation

The target, the mechanism of action, and the structure of the complex of RNAP with myxopyronin were first reported in 2008 by Richard H. Ebright and co-workers.{{Citation

Terence I. Moy and co-workers at Cubist Pharmaceuticals have stated that, based on high resistance rate and high serum protein binding (comparable to rifamycins and lipiarmycin), the unmodified natural product myxopyronin B is not a viable starting point for antibiotic development.{{Citation

References

References

  1. Kohl, Werner. "Myxopyronin A und B - zwei neue Antibiotika aus Myxococcus fulvus Stamm Mx f50".
  2. (2004). "Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation". Bioorganic & Medicinal Chemistry Letters.
  3. (2007). "Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase". Bioorganic & Medicinal Chemistry Letters.
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