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Myogenin

Mammalian protein found in Homo sapiens

Mammalian protein found in Homo sapiens

Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a myogenic regulatory factor (MRF), other examples of which also include MyoD, Myf5, and MRF4.

In mice, myogenin is essential for the development of functional skeletal muscle. Myogenin is required for the proper differentiation of most myogenic precursor cells during the process of myogenesis. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body.

In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types.

Interactions

Myogenin has been shown to interact with:

  • MDFI,
  • POLR2C,
  • Serum response factor
  • Sp1 transcription factor, and
  • TCF3.

References

References

  1. "MYOG - Myogenin - Homo sapiens (Human) - MYOG gene & protein".
  2. (August 1993). "Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene". Nature.
  3. (August 1993). "Myogenin gene disruption results in perinatal lethality because of severe muscle defect". Nature.
  4. (September 1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell.
  5. (October 2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". FASEB Journal.
  6. (March 1996). "Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins". The Journal of Biological Chemistry.
  7. (April 1999). "Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter". Molecular and Cellular Biology.
  8. (August 1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological Chemistry.
  9. (September 1992). "Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system". The Journal of Biological Chemistry.
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