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Myeloblastin

Class of enzymes

Class of enzymes

FieldValue
NameMyeloblastin
EC_number3.4.21.76
CAS_number128028-50-2

Myeloblastin (, leukocyte proteinase 3, leukocyte proteinase 4, proteinase PR-3, proteinase-3, PMNL proteinase) is an enzyme. This enzyme catalyses the following chemical reaction: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- -Val-

This enzyme is present in polymorphonuclear leukocyte granules. Downregulation of myeloblastin in promyelocytic leukemia cells was shown to induce their growth arrest and differentiation.

References

References

  1. (September 2017). "Proteinase 3: the odd one out that became an autoantigen". Journal of Leukocyte Biology.
  2. (November 1992). "Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters". Biochemical and Biophysical Research Communications.
  3. (February 1992). "Substrate and inhibitor studies on proteinase 3". FEBS Letters.
  4. (December 1989). "Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells". Cell.
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