Surf Wiki
Save to docs
general/cytokines

From Surf Wiki (app.surf) — the open knowledge base

Monokine

Type of cytokine produced primarily by monocytes and macrophages

Type of cytokine produced primarily by monocytes and macrophages

A monokine is a type of cytokine produced primarily by monocytes and macrophages.

Some monokines are:

  • interleukin 1
  • tumor necrosis factor-alpha
  • alpha and beta interferon
  • colony stimulating factors

Functions

Monokines released from macrophages can attract neutrophils, via the process chemotaxis.

The secretion of monokine, prompted by interferon gamma, has activity for the receptors found within immune cells, such as T-cells, hindering their ability to function as regulators of the body. Thus, promoting tumor progression in the cancer-state. In fact, its activity is important in other diseases, such as pulmonary tuberculosis, where researchers have identified monokine as a biomarker.

References

References

  1. {{MeshName. Monokines
  2. (1986). "Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome". The Journal of Experimental Medicine.
  3. (20 April 2009). "Illustrated dictionary of immunology". CRC Press.
  4. (November 2016). "Monokine induced by interferon gamma (MIG/CXCL9) is an independent prognostic factor in newly diagnosed myeloma". Leukemia & Lymphoma.
  5. (2020-11-20). "Monokine induced by gamma interferon for detecting pulmonary tuberculosis: A diagnostic meta-analysis". Medicine.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

cytokines
Want to explore this topic further?

Ask Mako anything about Monokine — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report