Surf Wiki
Save to docs
general/cell-signaling

From Surf Wiki (app.surf) — the open knowledge base

Mitochondrial apoptosis-induced channel

Mitochondrial apoptosis-induced channel
doi-access=free }}</ref>

The mitochondrial apoptosis-induced channel (or MAC), is an early marker of the onset of apoptosis. This ion channel is formed on the outer mitochondrial membrane in response to certain apoptotic stimuli. MAC activity is detected by patch clamping mitochondria from apoptotic cells at the time of cytochrome c release.

Members of the Bcl-2 protein family regulate apoptosis by controlling the formation of MAC: the pro-apoptotic members Bax and/or Bak form MAC, whereas the anti-apoptotic members like Bcl-2 or Bcl-xL prevent MAC formation. Once formed, MAC mediates the release of cytochrome c to the cytosol, triggering the commitment step of the mitochondrial apoptotic cascade. Depletion of MAC activity is accomplished pharmacologically by specific compounds, namely Bax channel inhibitors and MAC inhibitors. Either by knocking down MAC's main components or by its pharmacological inhibition, the end result is prevention of cytochrome c release and apoptosis.

References

References

  1. (2006). "Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins.". Biochim Biophys Acta.
  2. (2001). "A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast". J. Cell Biol..
  3. (2004). "Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC". Am. J. Physiol. Cell Physiol..
  4. (2006). "Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?". Cell Death and Differentiation.
  5. (2005). "Oligomeric Bax Is a Component of the Putative Cytochrome c Release Channel MAC, Mitochondrial Apoptosis-induced Channel". Mol. Biol. Cell.
  6. (2005). "Bax Channel Inhibitors Prevent Mitochondrion-mediated Apoptosis and Protect Neurons in a Model of Global Brain Ischemia". J. Biol. Chem..
  7. (2009). "MAC inhibitors suppress mitochondrial apoptosis". Biochem. J..
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

cell-signaling programmed-cell-death apoptosis
Want to explore this topic further?

Ask Mako anything about Mitochondrial apoptosis-induced channel — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report