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Metaclazepam

Chemical compound

Chemical compound

Metaclazepam (marketed under the brand name Talis) is a drug which is a benzodiazepine derivative. It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam. It has an active metabolite N-desmethylmetaclazepam, which is the main metabolite of metaclazepam. There is no significant difference in metabolism between younger and older individuals.

Metaclazepam is slightly more effective as an anxiolytic than bromazepam, or diazepam, with a 15 mg dose of metaclazepam equivalent to 4 mg of bromazepam. Metaclazepam can interact with alcohol producing additive sedative-hypnotic effects. Fatigue is a common side effect from metaclazepam at high doses. Small amounts of metaclazepam as well as its metabolites enter into human breast milk.

References

References

  1. {{cite patent
  2. (1984). "Metabolism and pharmacokinetics of metaclazepam (Talis), Part III: Determination of the chemical structure of metabolites in dogs, rabbits and men". European Journal of Drug Metabolism and Pharmacokinetics.
  3. (September 1986). "Analytical profile of metaclazepam". Arzneimittel-Forschung.
  4. (1985). "General pharmacology of the anxiolytic compound metaclazepam in comparison to other benzodiazepines". Arzneimittel-Forschung.
  5. (1986). "Pharmacokinetic profile of metaclazepam (Talis), a new 1.4-benzodiazepine. Influence of different dosage regimens on the pharmacokinetic profile of metaclazepam and its main metabolite under steady-state conditions". European Journal of Drug Metabolism and Pharmacokinetics.
  6. (1985). "Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers". European Journal of Clinical Pharmacology.
  7. (1988). "A double-blind comparison of the anxiolytic activity of two benzodiazepines, metaclazepam and bromazepam, in anxiety neurosis". Current Medical Research and Opinion.
  8. (May 1989). "Double-blind study of metaclazepam versus diazepam treatment of outpatients with anxiety syndrome". Pharmacopsychiatry.
  9. (1988). "Controlled study on the anxiolytic activity of a newly-developed benzodiazepine, metaclazepam". Current Medical Research and Opinion.
  10. (1983). "[Experimental studies on the interaction of alcohol and metaclazepam]". Beiträge zur Gerichtlichen Medizin.
  11. (May 1988). "Double-blind randomized trial of the benzodiazepine derivative metaclazepam as compared with placebo treatment of outpatients with anxiety syndromes". Pharmacopsychiatry.
  12. (November 1989). "Transfer of metaclazepam and its metabolites into breast milk". Arzneimittel-Forschung.
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benzodiazepines 2-chlorophenyl-compounds ethers bromoarenes
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