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MESTIT1 (gene)

In molecular biology, MEST intronic transcript 1, antisense RNA (non-protein coding), also known as MESTIT1 or PEG1-AS is a long non-coding RNA. It is an imprinted gene, which is paternally expressed. In humans, it is found on chromosome 7q32, imprinted genes on chromosome 7 are believed to be involved in Russell-Silver syndrome (RSS). However, it is believed that MESTIT1 is unlikely to cause Russell-Silver syndrome as there is a lack of mutations in this gene in Russell-Silver syndrome patients. MESTIT1 may regulate the expression of the MEST gene.

References

References

  1. (2002). "Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32.". Hum Mol Genet.
  2. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.". J Med Genet.
  3. (1998). "Evidence against a major role of PEG1/MEST in Silver-Russell syndrome.". Eur J Hum Genet.
  4. (2001). "No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients.". Am J Med Genet.
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