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Mesembrenone

Mesembrenone is an alkaloid constituent of Sceletium tortuosum (Kanna) and minor constituent of Lampranthus aureus and Lampranthus spectabilis.

Similar to modern synthetic antidepressants, it is a potent (IC50 i = 27 nM) and also a phosphodiesterase 4 (PDE4) inhibitor (Ki = 470 nM).

References

References

  1. (1998). "The Distribution of Mesembrine Alkaloids in Selected Taxa of the Mesembryanthemaceae and their Modification in the Sceletium Derived 'Kougoed'". Pharmaceutical Biology.
  2. (October 2011). "Pharmacological actions of the South African medicinal and [[functional food]] plant ''Sceletium tortuosum'' and its principal alkaloids". Journal of Ethnopharmacology.
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antidepressants indole-alkaloids ketones monoamine-releasing-agents phenol-ethers pde4-inhibitors serotonin-reuptake-inhibitors
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