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general/4-hydroxyphenyl-compounds

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Mequinol

Chemical compound

Chemical compound

| Drugs.com = | elimination_half-life =

Mequinol, MeHQ or 4-methoxyphenol, is an organic compound with the formula . It is a phenol with a methoxy group in the para position. A colorless solid, it is used in dermatology and organic chemistry.

Use in dermatology

Mequinol is a common active ingredient in topical drugs used for skin depigmentation. As a topical drug mequinol is often mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% mequinol and 0.01% tretinoin by mass. Dermatologists commonly prescribe the drug to treat liver spots.

Lower dosages of mequinol have been used in conjunction with a Q-switched laser to depigment skin in patients with disseminated idiopathic vitiligo.

Organic chemistry

In organic chemistry 4-methoxyphenol is used as a polymerisation inhibitor (e.g. acrylates or styrene monomers).

4-Methoxyphenol can be produced from p-benzoquinone and methanol via a free radical reaction.

Safety

The U.S. National Institute for Occupational Safety and Health (NIOSH) has set a recommended exposure limit (REL) of 5 mg/m3 over an 8-hour workday.

References

References

  1. Stiefel Laboratories, Inc.. "Full Prescribing Information". US Food and Drug Administration.
  2. (2000). "Hydroquinone".
  3. (December 2013). "Q-switched laser depigmentation in vitiligo, most effective in active disease". The British Journal of Dermatology.
  4. (2013). "Selective Monoetherification of 1,4-Hydroquinone Promoted by NaNO2". Current Organic Chemistry.
  5. "Process for the preparation of mono-ethers of hydroquinones".
  6. "4-Methoxyphenol". CDC.
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4-hydroxyphenyl-compounds 4-methoxyphenyl-compounds
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