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Meganuclease


  • Homing endonuclease
  • homologous recombination
  • I-CreI
  • Protein engineering
  • Protein design
  • Genome editing with engineered nucleases
  • Genome engineering
  • Genetic engineering

References

References

  1. (2006). "Homing endonuclease structure and function". Quarterly Reviews of Biophysics.
  2. (2003-06-01). "A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells". Nucleic Acids Research.
  3. (2007-08-03). "Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells". Journal of Molecular Biology.
  4. (2010-07-01). "Meganucleases can restore the reading frame of a mutated dystrophin". Gene Therapy.
  5. (2002). "Mutations altering the cleavage specificity of a homing endonuclease". Nucleic Acids Research.
  6. (2004). "Isolation and Characterization of New Homing Endonuclease Specificities at Individual Target Site Positions". Journal of Molecular Biology.
  7. (2006). "Homing endonuclease I-CreI derivatives with novel DNA target specificities". Nucleic Acids Research.
  8. (2006). "Engineering of Large Numbers of Highly Specific Homing Endonucleases that Induce Recombination on Novel DNA Targets". Journal of Molecular Biology.
  9. (2006). "A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences". Nucleic Acids Research.
  10. (2002). "Design, Activity, and Structure of a Highly Specific Artificial Endonuclease". Molecular Cell.
  11. (2009). "Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds". Nucleic Acids Research.
  12. (2010). "Heritable targeted mutagenesis in maize using a designed endonuclease". The Plant Journal.
  13. http://www.research.bayer.com/en/straight-into-the-cotton-genome.aspx{{full citation needed. (January 2013)
  14. (2014-02-01). "megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering". Nucleic Acids Research.
  15. (2012-10-01). "Coupling endonucleases with DNA end-processing enzymes to drive gene disruption". Nature Methods.
  16. (2013-01-01). "High frequency targeted mutagenesis using engineered endonucleases and DNA-end processing enzymes". PLOS ONE.
  17. (2012-08-31). "5′-Cytosine-Phosphoguanine (CpG) Methylation Impacts the Activity of Natural and Engineered Meganucleases". The Journal of Biological Chemistry.
  18. (2012-03-29). "Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases". Nucleic Acids Research.
  19. "US Patent for Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site Patent (Patent # 8,921,332 issued December 30, 2014) - Justia Patents Search".
  20. "Cellectis announces the issuance by the USPTO of a patent covering a seminal nuclease-based "gene editing" method {{!}} cellectis".
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