Surf Wiki
Save to docs
general/calcium-channel-blockers

From Surf Wiki (app.surf) — the open knowledge base

Manoalide

Manoalide is a calcium channel blocker. It has antibiotic, analgesic and anti-inflammatory effects and is found in some sponges, including the West Pacific species Luffariella variabilis. Its functions are made possible by the permanent blockage of phospholipase A2 and C with lysine residues. This could be made possible through the functional groups incorporated in gamma-hydroxybutenolide, alpha-hydroxydihydropyran and the trimethylcyclohexenyl. The gamma-hydroxybutenolide ring is present in the reaction between manoalide and phospholipase A2, the hemiacetal in alpha-hydroxydihydropyran is needed for permanent binding and hydrophobic trimethylcyclohexenyl ring makes it possible for non-bonded interactions to interact between manoalide and phospholipase A2 to strengthen the reaction. Due to its potential of permanent inhibition, it was made possible for it to take part in oral cancer and hepatitis C research.

References

References

  1. Brusca, Richard C. and Brusca, Gary J. ''Invertebrates''. 2nd ed. Sinauer Associates, 2002. p. 202.
  2. (2006). "Oxford dictionary of biochemistry and molecular biology". Oxford University Press.
  3. (2020-12-01). "Molecular Pharmacology: 98 (6)". Molecular Pharmacology.
  4. (2019). "Manoalide Preferentially Provides Antiproliferation of Oral Cancer Cells by Oxidative Stress-Mediated Apoptosis and DNA Damage". Cancers.
  5. (2012). "Inhibition of Hepatitis C Virus NS3 Helicase by Manoalide". Journal of Natural Products.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

calcium-channel-blockers furanones secondary-alcohols cyclohexenes
Want to explore this topic further?

Ask Mako anything about Manoalide — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report