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Malate dehydrogenase (decarboxylating)

Enzyme

Field	Value
Name	NAD-malic enzyme
EC_number	1.1.1.39
CAS_number	9028-46-0
GO_code	0004471
image	1efk.jpg
width	270
caption	malic enzyme tetramer, Human

Malate dehydrogenase (decarboxylating) () or NAD-malic enzyme (NAD-ME) is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (S)-malic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are pyruvic acid, carbon dioxide, and reduced NADH.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in pyruvate metabolism and carbon fixation. NAD-malic enzyme is one of three decarboxylation enzymes used in the inorganic carbon concentrating mechanisms of C4 and CAM plants. The others are NADP-malic enzyme and PEP carboxykinase.

References

{{KEGG enzyme. 1.1.1.39
(1957). "The oxidative decarboxylation of malate by ''Ascaris lumbricoides''". J. Biol. Chem..

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ec-1.1.1 nadh-dependent-enzymes

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