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Magnolol

5,5'-Diallyl-2,2'-dihydroxybiphenyl 5,5'-Diallyl-2,2'-biphenyldiol

Magnolol is an organic compound that is classified as lignan. It is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis) and in M. grandiflora.

Magnolol is a compound that acts on GABAA receptors and functions as an allosteric modulator. It has antifungal properties and demonstrates anti-periodontal disease effects in animal models. In cell cultures, magnolol stimulates osteoblasts and inhibits osteoclasts, indicating potential for anti-osteoporosis treatment. It also binds in a dimeric form to PPARγ, acting as an agonist of this nuclear receptor. Additionally, magnolol may interact with cannabinoid receptors, acting as a partial agonist of CB2 receptors with lower affinity for CB1 receptors.

Bioactivity

It is known to act on the GABAA receptors in rat cells in vitro as well as having antifungal properties. Magnolol has a number of osteoblast-stimulating and osteoclast-inhibiting activities in cell culture and has been suggested as a candidate for screening for anti-osteoporosis activity. It has anti-periodontal disease activity in a rat model. Structural analogues have been studied and found to be strong allosteric modulators of GABAA.

Magnolol is also binding in dimeric mode to PPARγ, acting as an agonist of this nuclear receptor.

Magnolol may interact with cannabinoid receptors, acting as a partial agonist of CB2 receptors, with lower affinity for the CB1 receptor.

References

References

  1. [http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=en&N4=M3445|SIGMA&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC Magnolol] at Sigma-Aldrich
  2. (2011). "Therapeutic applications of compounds in the ''Magnolia'' family". Pharmacology & Therapeutics.
  3. (2001). "Honokiol and Magnolol Selectively Interact with GABAA Receptor Subtypes in vitro". Pharmacology.
  4. (2000). "Antifungal activity of magnolol and honokiol". Archives of Pharmacal Research.
  5. (2012). "Effect of Magnolol on the Function of Osteoblastic MC3T3-E1 Cells". Mediators of Inflammation.
  6. (2013). "Magnolol Ameliorates Ligature-Induced Periodontitis in Rats and Osteoclastogenesis: In Vivo and in Vitro Study". Evidence-Based Complementary and Alternative Medicine.
  7. (December 2014). "Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABAA receptors". Bioorganic & Medicinal Chemistry.
  8. (20 October 2017). "Linked magnolol dimer as a selective PPARγ agonist – Structure-based rational design, synthesis, and bioactivity evaluation". Scientific Reports.
  9. (10 January 2013). "Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB 2 Receptors and Blockade of the Related GPR55". ACS Medicinal Chemistry Letters.
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gabaa-receptor-positive-allosteric-modulators cannabinoids biphenyls lignans phenols allylbenzenes symmetrical-biaryls
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