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Lysidine (chemical)
Lysidine is a derivative of 2-imidazoline. It is a colorless solid with basic properties and soluble in organic solvents. It is used as a precursor to other compounds of pharmaceutical interest.
Synthesis and reactions
It is prepared by condensing ethylenediamine with acetic acid to give the diamide, which undergoes CaO-induced cyclization. Lysidine is an intermediate in the synthesis of the drug metronidazole. In the presence of Raney nickel, it undergoes dehydrogenation to 2-methylimidazole, which can then be further elaborated.
References
References
- [https://www.sigmaaldrich.com/CZ/en/product/aldrich/375403 Lysidine] at [[Sigma-Aldrich]]
- "Lysidine".
- (1989). "Synthesis of metronidazole from ethylenediamine". Pharmaceutical Chemistry Journal.
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