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Long range pseudoknots
| Field | Value |
|---|---|
| Name | Long range pseudoknot |
| image | RF01086.png |
| width | 200 |
| caption | Secondary structure of the long range pseudoknot |
| Rfam | RF01086 |
| RNA_type | Cis-reg |
| Tax_domain | Eukaryote Prokaryote |
A long range pseudoknot is a pseudoknot containing a long loop region, and may be a mechanism of translational control.
A long range pseudoknot is thought to negatively regulate the translation of the IF3-L35-L20 operon in E. coli. This operon encodes the translation initiation factor IF-3 and ribosomal proteins L35 and L20. In this example, the RNA-RNA interaction occurs between nucleotides separated by a 300 nucleotide loop region.
A long range pseudoknot is also believed to be required for the activity of the Neurospora VS ribozyme.
References
References
- (August 1996). "A long-range RNA-RNA interaction forms a pseudoknot required for translational control of the IF3-L35-L20 ribosomal protein operon in Escherichia coli". The EMBO Journal.
- (June 1996). "A long-range pseudoknot is required for activity of the Neurospora VS ribozyme". The EMBO Journal.
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