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Litoxetine

Chemical compound

Chemical compound

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Litoxetine (developmental code names SL 81-0385, IXA-001) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s but was never marketed. It acts as a potent serotonin reuptake inhibitor (Ki for = 7 nM) and modest 5-HT3 receptor antagonist (Ki = 315 nM). It has antiemetic activity, and unlike the selective serotonin reuptake inhibitors (SSRIs), appears to have a negligible incidence of nausea and vomiting. The drug is structurally related to indalpine. Development of litoxetine for depression was apparently ceased in the late 1990s. However, as of March 2017, development of litoxetine has been reinitiated and the drug is now in the phase II stage for the treatment of urinary incontinence.

References

References

  1. "Litoxetine - IXALTIS". Springer Nature Switzerland AG.
  2. (August 1995). "The psychomotor and cognitive effects of litoxetine in young and middle aged volunteers". British Journal of Clinical Pharmacology.
  3. (8 October 2012). "Drug Discovery for Psychiatric Disorders". Royal Society of Chemistry.
  4. (6 December 2012). "Progress in Drug Research". Birkhäuser.
  5. (March 1993). "Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties". European Journal of Pharmacology.
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5-ht3-antagonists antidepressants ethers 2-naphthyl-compounds 4-piperidinyl-compounds serotonin-reuptake-inhibitors
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