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List of autoimmune diseases
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This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed with the condition. Each disorder is also categorized by its acceptance as an autoimmune condition into four levels: confirmed, probable, possible, and uncertain. This classification is based on the current scientific consensus and reflects the level of evidence supporting the autoimmune nature of the disorder. Lastly, the prevalence rate, specifically in the United States, is included to give a sense of how common each disorder is within the population.
- Confirmed – Used for conditions that have strong, well-established evidence of autoimmune etiology.
- Probable – Used for conditions where there is substantial evidence of autoimmune involvement, but the scientific consensus may not be as strong as for those in the 'confirmed' category.
- Possible – Used for conditions that have some evidence pointing towards autoimmune involvement, but it's not yet clear or there is ongoing debate.
- Uncertain – Used for conditions where the evidence of autoimmune involvement is limited or contested.
Integumentary system
The integumentary system, composed of the skin, hair, nails, and associated glands, serves as a protective barrier between the body and the environment. It also plays a critical role in regulating body temperature and maintaining fluid balance.
| Disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alopecia areata | Hair follicles | None specific | Confirmed | 2.1% | last1=Pratt | first1=C. Herbert | last2=King | first2=Lloyd E. | last3=Messenger | first3=Andrew G. | last4=Christiano | first4=Angela M. | last5=Sundberg | first5=John P. | title=Alopecia areata | journal=Nature Reviews Disease Primers | publisher=Springer Science and Business Media LLC | volume=3 | issue=1 | date=2017-03-16 | issn=2056-676X | doi=10.1038/nrdp.2017.11 | page=17011 | pmid=28300084 | pmc=5573125 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Autoimmune angioedema | Skin | C1 inhibitor | Probable | Less than 5,000 | title=Acquired angioedema - About the Disease | website=Genetic and Rare Diseases Information Center | date=2021-01-08 | url=https://rarediseases.info.nih.gov/diseases/8605/acquired-angioedema | access-date=2023-07-12}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Autoimmune progesterone dermatitis | Skin | Progesterone | Probable | Extremely rare | last1=Irshad | first1=Shahmeen | last2=Haider | first2=Muhammad S | last3=Master | first3=Madiha F | last4=Asif | first4=Nasir | last5=Khalil | first5=Ambreen | title=Autoimmune Progesterone Dermatitis | journal=Cureus | publisher=Cureus, Inc. | date=2021-11-02 | volume=13 | issue=11 | article-number=e19217 | issn=2168-8184 | doi=10.7759/cureus.19217 | doi-access=free | pmid=34877200 | pmc=8642151 }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Autoimmune urticaria | Skin | IgG against IgE or IgE receptor | Probable | Not well established | last1=Kolkhir | first1=Pavel | last2=Muñoz | first2=Melba | last3=Asero | first3=Riccardo | last4=Ferrer | first4=Marta | last5=Kocatürk | first5=Emek | last6=Metz | first6=Martin | last7=Xiang | first7=Yi-Kui | last8=Maurer | first8=Marcus | title=Autoimmune chronic spontaneous urticaria | journal=Journal of Allergy and Clinical Immunology | publisher=Elsevier BV | volume=149 | issue=6 | year=2022 | issn=0091-6749 | doi=10.1016/j.jaci.2022.04.010 | pages=1819–1831 | pmid=35667749 | s2cid=249362247 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Bullous pemphigoid | Skin | Anti-BP180, Anti-BP230 | Confirmed | 6-30 per 100,000 (mostly older adults) | last1=Cole | first1=Connor | last2=Vinay | first2=Keshavamurthy | last3=Borradori | first3=Luca | last4=Amber | first4=Kyle T. | title=Insights Into the Pathogenesis of Bullous Pemphigoid: The Role of Complement-Independent Mechanisms | journal=Frontiers in Immunology | publisher=Frontiers Media SA | volume=13 | date=2022-07-07 | issn=1664-3224 | doi=10.3389/fimmu.2022.912876 | page= | pmid=35874745 | pmc=9300999 | doi-access=free }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cicatricial pemphigoid | Mucous membranes, sometimes skin | Anti-BP180, Anti-BP230 | Confirmed | Rare | last1=Rashid | first1=H. | last2=Lamberts | first2=A. | last3=Borradori | first3=L. | last4=Alberti-Violetti | first4=S. | last5=Barry | first5=R.J. | last6=Caproni | first6=M. | last7=Carey | first7=B. | last8=Carrozzo | first8=M. | last9=Caux | first9=F. | last10=Cianchini | first10=G. | last11=Corrà | first11=A. | last12=Diercks | first12=G.F.H. | last13=Dikkers | first13=F.G. | last14=Di Zenzo | first14=G. | last15=Feliciani | first15=C. | last16=Geerling | first16=G. | last17=Genovese | first17=G. | last18=Hertl | first18=M. | last19=Joly | first19=P. | last20=Marzano | first20=A.V. | last21=Meijer | first21=J.M. | last22=Mercadante | first22=V. | last23=Murrell | first23=D.F. | last24=Ormond | first24=M. | last25=Pas | first25=H.H. | last26=Patsatsi | first26=A. | last27=Prost | first27=C. | last28=Rauz | first28=S. | last29=Rhijn | first29=B.D. | last30=Roth | first30=M. | last31=Schmidt | first31=E. | last32=Setterfield | first32=J. | last33=Zambruno | first33=G. | last34=Zillikens | first34=D. | last35=Horváth | first35=B. | title=European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology – Part I | journal=Journal of the European Academy of Dermatology and Venereology | publisher=Wiley | volume=35 | issue=9 | date=2021-07-10 | issn=0926-9959 | doi=10.1111/jdv.17397 | pages=1750–1764 | pmid=34245180 | pmc=8457055 }} |
| Dermatitis herpetiformis | Skin | Anti-tissue transglutaminase | Confirmed | 10 per 100,000 | last1=Reunala | first1=Timo | last2=Hervonen | first2=Kaisa | last3=Salmi | first3=Teea | title=Dermatitis Herpetiformis: An Update on Diagnosis and Management | journal=American Journal of Clinical Dermatology | publisher=Springer Science and Business Media LLC | volume=22 | issue=3 | date=2021-01-11 | issn=1175-0561 | doi=10.1007/s40257-020-00584-2 | pages=329–338 | pmid=33432477 | pmc=8068693 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DermatomyositisDermatomyositis | Skin and muscles | Anti-Jo1, Anti-Mi2, Anti-SRP, Anti-TIF1 | Confirmed | 9 in 1,000,000 | last1=Nombel | first1=Anaïs | last2=Fabien | first2=Nicole | last3=Coutant | first3=Frédéric | title=Dermatomyositis With Anti-MDA5 Antibodies: Bioclinical Features, Pathogenesis and Emerging Therapies | journal=Frontiers in Immunology | publisher=Frontiers Media SA | volume=12 | date=2021-10-20 | issn=1664-3224 | doi=10.3389/fimmu.2021.773352 | page= | pmid=34745149 | pmc=8564476 | doi-access=free }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Discoid lupus erythematosus | Skin | ANA, Anti-dsDNA, Anti-Sm | Confirmed | Part of SLE prevalence (20-150 per 100,000) | last1=Donnelly | first1=AM | last2=Halbert | first2=AR | last3=Rohr | first3=JB | title=Discoid lupus erythematosus | journal=Australasian Journal of Dermatology | publisher=Wiley | volume=36 | issue=1 | year=1995 | issn=0004-8380 | doi=10.1111/j.1440-0960.1995.tb00916.x | pages=3–10 | pmid=7763220 | s2cid=9050427 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Epidermolysis bullosa acquisita | Skin | Anti-type VII collagen | Confirmed | Extremely rare | last1=Miyamoto | first1=Denise | last2=Gordilho | first2=Juliana Olivieri | last3=Santi | first3=Claudia Giuli | last4=Porro | first4=Adriana Maria | title=Epidermolysis bullosa acquisita | journal=Anais Brasileiros de Dermatologia | publisher=Elsevier BV | volume=97 | issue=4 | year=2022 | issn=0365-0596 | doi=10.1016/j.abd.2021.09.010 | pages=409–423 | pmid=35701269 | pmc=9263658 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Erythema nodosum | Skin | None specific | Possible | Not well established | last1=Pérez-Garza | first1=Daniela Michelle | last2=Chavez-Alvarez | first2=Sonia | last3=Ocampo-Candiani | first3=Jorge | last4=Gomez-Flores | first4=Minerva | title=Erythema Nodosum: A Practical Approach and Diagnostic Algorithm | journal=American Journal of Clinical Dermatology | publisher=Springer Science and Business Media LLC | volume=22 | issue=3 | date=2021-03-08 | issn=1175-0561 | doi=10.1007/s40257-021-00592-w | pages=367–378 | pmid=33683567 | pmc=7938036 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gestational pemphigoid | Skin | Anti-BP180, Anti-BP230 | Confirmed | Rare | last1=Patel | first1=Payal M. | last2=Jones | first2=Virginia A. | last3=Murray | first3=Taryn N. | last4=Amber | first4=Kyle T. | title=A Review Comparing International Guidelines for the Management of Bullous Pemphigoid, Pemphigoid Gestationis, Mucous Membrane Pemphigoid, and Epidermolysis Bullosa Acquisita | journal=American Journal of Clinical Dermatology | publisher=Springer Science and Business Media LLC | volume=21 | issue=4 | date=2020-03-16 | issn=1175-0561 | doi=10.1007/s40257-020-00513-3 | pages=557–565 | pmid=32180161 | s2cid=212718889 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Hidradenitis suppurativa | Skin | None specific | Uncertain | 1-4% | last1=Goldburg | first1=Samantha R. | last2=Strober | first2=Bruce E. | last3=Payette | first3=Michael J. | title=Hidradenitis suppurativa | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=82 | issue=5 | year=2020 | issn=0190-9622 | doi=10.1016/j.jaad.2019.08.090 | pages=1045–1058 | pmid=31604104 | s2cid=243497119 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lichen planus | Skin, mucous membranes | None specific | Probable | 1% | last1=Tziotzios | first1=Christos | last2=Lee | first2=John Y.W. | last3=Brier | first3=Timothy | last4=Saito | first4=Ryo | last5=Hsu | first5=Chao-Kai | last6=Bhargava | first6=Kapil | last7=Stefanato | first7=Catherine M. | last8=Fenton | first8=David A. | last9=McGrath | first9=John A. | title=Lichen planus and lichenoid dermatoses | journal=Journal of the American Academy of Dermatology | publisher=Elsevier BV | volume=79 | issue=5 | year=2018 | issn=0190-9622 | doi=10.1016/j.jaad.2018.02.010 | pages=789–804 | pmid=30318136 | s2cid=52982317 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Lichen sclerosus | Skin | None specific | Probable | Rare | last=Kirtschig | first=Gudula | title=Lichen Sclerosus—Presentation, Diagnosis and Management | journal=Deutsches Ärzteblatt International | publisher=Deutscher Arzte-Verlag GmbH | date=2016-05-13 | volume=113 | issue=19 | pages=337–343 | issn=1866-0452 | doi=10.3238/arztebl.2016.0337 | pmid=27232363 | pmc=4904529 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Linear IgA disease | Skin | Anti-epidermal basement membrane IgA | Confirmed | Extremely rare | last1=Shin | first1=Leah | last2=Gardner | first2=Jeffrey T. | last3=Dao | first3=Harry | title=Updates in the Diagnosis and Management of Linear IgA Disease: A Systematic Review | journal=Medicina | publisher=MDPI AG | volume=57 | issue=8 | date=2021-08-12 | issn=1648-9144 | doi=10.3390/medicina57080818 | page=818 | pmid=34441024 | pmc=8400507 | doi-access=free }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Morphea | Skin | None specific | Probable | Not well established | last1=Florez-Pollack | first1=Stephanie | last2=Kunzler | first2=Elaine | last3=Jacobe | first3=Heidi T. | title=Morphea: Current concepts | journal=Clinics in Dermatology | publisher=Elsevier BV | volume=36 | issue=4 | year=2018 | issn=0738-081X | doi=10.1016/j.clindermatol.2018.04.005 | pages=475–486 | pmid=30047431 | s2cid=206776415 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Psoriasis | Skin | Various, not specific | Confirmed | 2-3% | last1=Boehncke | first1=Wolf-Henning | last2=Schön | first2=Michael P | title=Psoriasis | journal=The Lancet | publisher=Elsevier BV | volume=386 | issue=9997 | year=2015 | issn=0140-6736 | doi=10.1016/s0140-6736(14)61909-7 | pages=983–994 | pmid=26025581 }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pemphigus vulgaris | Skin and mucous membranes | Anti-desmoglein 3, Anti-desmoglein 1 | Confirmed | 1-5 per 100,000 | last1=Melchionda | first1=V. | last2=Harman | first2=K. E. | title=Pemphigus vulgaris and pemphigus foliaceus: an overview of the clinical presentation, investigations and management | journal=Clinical and Experimental Dermatology | publisher=Oxford University Press (OUP) | volume=44 | issue=7 | date=2019-08-04 | issn=0307-6938 | doi=10.1111/ced.14041 | pages=740–746 | pmid=31378971 | s2cid=199436546 | doi-access=free }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Scleroderma (systemic sclerosis) | Skin, organs | ANA, anti-Scl-70, anti-centromere | Confirmed | 240 per 1,000,000 | last1=Careta | first1=Mariana Figueiroa | last2=Romiti | first2=Ricardo | title=Localized scleroderma: clinical spectrum and therapeutic update | journal=Anais Brasileiros de Dermatologia | publisher=FapUNIFESP (SciELO) | volume=90 | issue=1 | year=2015 | issn=0365-0596 | doi=10.1590/abd1806-4841.20152890 | pages=62–73 | pmid=25672301 | pmc=4323700 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sjögren syndrome | Exocrine glands (salivary and lacrimal glands) | Anti-SSA/Ro, Anti-SSB/La antibodies, anti-centromere | Confirmed | 0.1-4% of the population | last1=Brito-Zerón | first1=Pilar | last2=Retamozo | first2=Soledad | last3=Ramos-Casals | first3=Manuel | title=Síndrome de Sjögren | journal=Medicina Clínica | publisher=Elsevier BV | volume=160 | issue=4 | year=2023 | issn=0025-7753 | doi=10.1016/j.medcli.2022.10.007 | pages=163–171 | pmid=36528400 | s2cid=263009504 | language=es}} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Vitiligo | Skin | Various, not specific | Confirmed | 1% | last1=Bergqvist | first1=Christina | last2=Ezzedine | first2=Khaled | title=Vitiligo: A Review | journal=Dermatology | publisher=S. Karger AG | volume=236 | issue=6 | year=2020 | issn=1018-8665 | doi=10.1159/000506103 | pages=571–592 | pmid=32155629 | s2cid=212666272 | doi-access=free }} |
Digestive system
| Autoimmune disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Autoimmune enteropathy | Small intestine | Anti-enterocyte antibodies | Probable | Rare | last1=Chen | first1=Charles B. | last2=Tahboub | first2=Farah | last3=Plesec | first3=Thomas | last4=Kay | first4=Marsha | last5=Radhakrishnan | first5=Kadakkal | title=A Review of Autoimmune Enteropathy and Its Associated Syndromes | journal=Digestive Diseases and Sciences | publisher=Springer Science and Business Media LLC | volume=65 | issue=11 | date=2020-08-24 | issn=0163-2116 | doi=10.1007/s10620-020-06540-8 | pages=3079–3090 | pmid=32833153 | s2cid=221257881 }} | ||
| Autoimmune hepatitis | Liver | ANA, ASMA, anti-LKM1 | Confirmed | 1 in 10,000 to 1 in 50,000 | last1=Sucher | first1=Elisabeth | last2=Sucher | first2=Robert | last3=Gradistanac | first3=Tanja | last4=Brandacher | first4=Gerald | last5=Schneeberger | first5=Stefan | last6=Berg | first6=Thomas | title=Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies | journal=Journal of Immunology Research | publisher=Hindawi Limited | volume=2019 | date=2019-11-25 | issn=2314-8861 | doi=10.1155/2019/9437043 | pages=1–19 | pmid=31886312 | pmc=6899271 | doi-access=free }} |
| Celiac disease | Small intestine | Anti-tissue transglutaminase antibodies (tTG), Endomysial antibody (EMA), Deamidated gliadin peptide (DGP) | Confirmed | 1 in 100 | last1=Catassi | first1=Carlo | last2=Verdu | first2=Elena F | last3=Bai | first3=Julio Cesar | last4=Lionetti | first4=Elena | title=Coeliac disease | journal=The Lancet | publisher=Elsevier BV | volume=399 | issue=10344 | year=2022 | issn=0140-6736 | doi=10.1016/s0140-6736(22)00794-2 | pages=2413–2426 | pmid=35691302 | s2cid=249622609 }} | ||||
| Crohn's disease | Digestive tract | ASCA, Anti-OmpC, Anti-CBir1, ANCA | Probable | 201 per 100,000 adults | last1=Torres | first1=Joana | last2=Mehandru | first2=Saurabh | last3=Colombel | first3=Jean-Frédéric | last4=Peyrin-Biroulet | first4=Laurent | title=Crohn's disease | journal=The Lancet | publisher=Elsevier BV | volume=389 | issue=10080 | year=2017 | issn=0140-6736 | doi=10.1016/s0140-6736(16)31711-1 | pages=1741–1755 | pmid=27914655 | s2cid=13678540 }} | ||||
| Intestinal necrotizing arteriolitis | Liver, pancreas and intestines. | None specific | Possible | ||||||||||||||||||||||||
| Pernicious anemia | Stomach | Anti-IF, Anti-parietal cell | Confirmed | 0.1% | last1=Mohamed | first1=Muhajir | last2=Thio | first2=Joel | last3=Thomas | first3=Remy Susan | last4=Phillips | first4=Jehan | title=Pernicious anaemia | journal=BMJ | date=2020-04-24 | volume=369 | issn=1756-1833 | doi=10.1136/bmj.m1319 | article-number=m1319 | pmid=32332011 | s2cid=216129306 }} | ||||||
| Ulcerative colitis | Colon and rectum | pANCA, ASCA | Probable | 249 per 100,000 adults | last1=Ordás | first1=Ingrid | last2=Eckmann | first2=Lars | last3=Talamini | first3=Mark | last4=Baumgart | first4=Daniel C | last5=Sandborn | first5=William J | title=Ulcerative colitis | journal=The Lancet | publisher=Elsevier BV | volume=380 | issue=9853 | year=2012 | issn=0140-6736 | doi=10.1016/s0140-6736(12)60150-0 | pages=1606–1619 | pmid=22914296 | s2cid=18349657 }} |
Heart and vascular system
| Autoimmune disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. | ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rheumatic heart disease | Heart valves | Anti-streptolysin O (ASO), anti-DNase B | Confirmed | Declining due to improved treatment of strep throat | last1=Carapetis | first1=Jonathan R. | last2=Beaton | first2=Andrea | last3=Cunningham | first3=Madeleine W. | last4=Guilherme | first4=Luiza | last5=Karthikeyan | first5=Ganesan | last6=Mayosi | first6=Bongani M. | last7=Sable | first7=Craig | last8=Steer | first8=Andrew | last9=Wilson | first9=Nigel | last10=Wyber | first10=Rosemary | last11=Zühlke | first11=Liesl | title=Acute rheumatic fever and rheumatic heart disease | journal=Nature Reviews Disease Primers | publisher=Springer Science and Business Media LLC | volume=2 | issue=1 | date=2016-01-14 | issn=2056-676X | doi=10.1038/nrdp.2015.84 | page=15084 | pmid=27188830 | pmc=5810582 }} |
| Kawasaki disease | Coronary arteries | Unknown | Probable | 20 per 100,000 children under age 5 | last1=Rife | first1=Eileen | last2=Gedalia | first2=Abraham | title=Kawasaki Disease: an Update | journal=Current Rheumatology Reports | publisher=Springer Science and Business Media LLC | volume=22 | issue=10 | date=2020-09-13 | issn=1523-3774 | doi=10.1007/s11926-020-00941-4 | page=75 | pmid=32924089 | pmc=7487199 }} | ||||||||||||||||||
| Giant cell arteritis | Large and medium arteries, can affect coronary arteries | None specific | Confirmed | 200 per 100,000 (over age 50) | |||||||||||||||||||||||||||||||||
| Takayasu's arteritis | Large arteries, including the aorta | None specific | Confirmed | Rare, more common in East Asia | last1=Galarza | first1=Claudio | last2=Valencia | first2=Diana | last3=Tobón | first3=Gabriel J. | last4=Zurita | first4=Luis | last5=Mantilla | first5=Rubén D. | last6=Pineda-Tamayo | first6=Ricardo | last7=Rojas-Villarraga | first7=Adriana | last8=Rueda | first8=Juan C. | last9=Anaya | first9=Juan-Manuel | title=Should Rituximab be Considered as the First-Choice Treatment for Severe Autoimmune Rheumatic Diseases? | journal=Clinical Reviews in Allergy & Immunology | publisher=Springer Science and Business Media LLC | volume=34 | issue=1 | date=2007-09-22 | issn=1080-0549 | doi=10.1007/s12016-007-8028-z | pages=124–128 | pmid=18270866 | s2cid=21279076 }} | ||||
| Behçet's disease | Small to large vessels in mouth, genitals, eyes, skin | None specific | Probable | last1=Tong | first1=Bainan | last2=Liu | first2=Xiaoli | last3=Xiao | first3=Jun | last4=Su | first4=Guanfang | title=Immunopathogenesis of Behcet's Disease | journal=Frontiers in Immunology | publisher=Frontiers Media SA | volume=10 | date=2019-03-29 | issn=1664-3224 | doi=10.3389/fimmu.2019.00665 | page=665 | pmid=30984205 | pmc=6449449 | doi-access=free }} | |||||||||||||||
| EGPAEosinophilic granulomatosis with polyangiitis (EGPA) | Small to medium vessels in respiratory tract, skin, heart, kidneys, nerves | ANCA | Confirmed | last1=White | first1=JPE | last2=Dubey | first2=S. | title=Eosinophilic granulomatosis with polyangiitis: A review | journal=Autoimmunity Reviews | publisher=Elsevier BV | volume=22 | issue=1 | year=2023 | issn=1568-9972 | doi=10.1016/j.autrev.2022.103219 | article-number=103219 | pmid=36283646 | s2cid=253087925 | doi-access=free }} | ||||||||||||||||||
| GPAGranulomatosis with polyangiitis (GPA) | Small to medium vessels in respiratory tract, kidneys | c-ANCA/PR3-ANCA | Confirmed | ||||||||||||||||||||||||||||||||||
| IgA vasculitis (IgAV) | Small vessels in skin, joints, kidneys, gastrointestinal tract | IgA immune complexes | Probable | last1=Pillebout | first1=Evangéline | last2=Sunderkötter | first2=Cord | title=IgA vasculitis | journal=Seminars in Immunopathology | publisher=Springer Science and Business Media LLC | volume=43 | issue=5 | date=2021-06-25 | issn=1863-2297 | doi=10.1007/s00281-021-00874-9 | pages=729–738 | pmid=34170395 | s2cid=235635414 }} | |||||||||||||||||||
| Leukocytoclastic vasculitis | Small vessels in skin | Various immune complexes | Probable | last1=Fraticelli | first1=Paolo | last2=Benfaremo | first2=Devis | last3=Gabrielli | first3=Armando | title=Diagnosis and management of leukocytoclastic vasculitis | journal=Internal and Emergency Medicine | publisher=Springer Science and Business Media LLC | volume=16 | issue=4 | date=2021-03-13 | issn=1828-0447 | doi=10.1007/s11739-021-02688-x | pages=831–841 | pmid=33713282 | pmc=8195763 }} | |||||||||||||||||
| Lupus vasculitis | Small to medium vessels in multiple organs | ANA, anti-dsDNA, anti-Smith, others | Confirmed | last1=Calle-Botero | first1=Estefania | last2=Abril | first2=Andy | title=Lupus Vasculitis | journal=Current Rheumatology Reports | publisher=Springer Science and Business Media LLC | volume=22 | issue=10 | date=2020-08-26 | issn=1523-3774 | doi=10.1007/s11926-020-00937-0 | page=71 | pmid=32845454 | s2cid=221329029 }} | |||||||||||||||||||
| Rheumatoid vasculitis | Small to medium vessels in skin, nerves, eyes, heart | Rheumatoid factor, ACPA | Probable | last1=Mertz | first1=Philippe | last2=Wollenschlaeger | first2=Clara | last3=Chasset | first3=François | last4=Dima | first4=Alina | last5=Arnaud | first5=Laurent | title=Rheumatoid vasculitis in 2023: Changes and challenges since the biologics era | journal=Autoimmunity Reviews | publisher=Elsevier BV | volume=22 | issue=9 | year=2023 | issn=1568-9972 | doi=10.1016/j.autrev.2023.103391 | article-number=103391 | pmid=37468085 | s2cid=259957955 }} | |||||||||||||
| Microscopic polyangiitis (MPA) | Small vessels in kidneys, lungs, nerves, skin | p-ANCA/MPO-ANCA | Confirmed | last1=Greco | first1=Antonio | last2=De Virgilio | first2=Armando | last3=Rizzo | first3=Maria Ida | last4=Gallo | first4=Andrea | last5=Magliulo | first5=Giuseppe | last6=Fusconi | first6=Massimo | last7=Ruoppolo | first7=Giovanni | last8=Tombolini | first8=Mario | last9=Turchetta | first9=Rosaria | last10=de Vincentiis | first10=Marco | title=Microscopic polyangiitis: Advances in diagnostic and therapeutic approaches | journal=Autoimmunity Reviews | publisher=Elsevier BV | volume=14 | issue=9 | year=2015 | issn=1568-9972 | doi=10.1016/j.autrev.2015.05.005 | pages=837–844 | pmid=25992801 }} | ||||
| Necrotizing arteriolitis | Medium vessels in kidneys and adrenals. | None specific | Possible | title=Pathogenesis of Hypertensive Arterial Necrosis | journal=JAMA | date=September 24, 1949 | volume=141 | issue=4 | page=4 | doi=10.1001/jama.1949.02910040028008 }} | |||||||||||||||||||||||||||
| Polyarteritis nodosa (PAN) | Medium to small vessels in kidneys, skin, muscles, joints, nerves | None specific | Probable | last1=Bilginer | first1=Yelda | last2=Ozen | first2=Seza | title=Polyarteritis nodosa | journal=Current Opinion in Pediatrics | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=34 | issue=2 | date=2022-01-25 | issn=1040-8703 | doi=10.1097/mop.0000000000001106 | pages=229–233 | pmid=35081554 | s2cid=246296626 }} | |||||||||||||||||||
| Polymyalgia rheumatica | Large to medium vessels in shoulders, hips | None specific | Possible | last1=Lundberg | first1=Ingrid E. | last2=Sharma | first2=Ankita | last3=Turesson | first3=Carl | last4=Mohammad | first4=Aladdin J. | title=An update on polymyalgia rheumatica | journal=Journal of Internal Medicine | publisher=Wiley | volume=292 | issue=5 | date=2022-06-11 | issn=0954-6820 | doi=10.1111/joim.13525 | pages=717–732 | pmid=35612524 | pmc=9796644 }} | |||||||||||||||
| Urticarial vasculitis | Small vessels in skin | C1q antibodies | Probable | last1=Gu | first1=Stephanie L. | last2=Jorizzo | first2=Joseph L. | title=Urticarial vasculitis | journal=International Journal of Women's Dermatology | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=7 | issue=3 | year=2021 | issn=2352-6475 | doi=10.1016/j.ijwd.2021.01.021 | pages=290–297 | pmid=34222586 | pmc=8243153 }} | |||||||||||||||||||
| Vasculitis | All vessel sizes in multiple organs | Depends on specific type | Uncertain | last1=Kermani | first1=Tanaz A. | last2=Warrington | first2=Kenneth J. | last3=Dua | first3=Anisha B. | title=Treatment Guidelines in Vasculitis | journal=Rheumatic Disease Clinics of North America | publisher=Elsevier BV | volume=48 | issue=3 | year=2022 | issn=0889-857X | doi=10.1016/j.rdc.2022.03.006 | pages=705–724 | pmid=35953232 | s2cid=250323897 }} |
Urinary system
| Autoimmune disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Goodpasture Goodpasture syndrome | Kidneys, lungs | Anti-GBM antibodies | Confirmed | 1 per million people | last1=Reggiani | first1=Francesco | last2=L'Imperio | first2=Vincenzo | last3=Calatroni | first3=Marta | last4=Pagni | first4=Fabio | last5=Sinico | first5=Renato Alberto | title=Goodpasture syndrome and anti-glomerular basement membrane disease | journal=Clinical and Experimental Rheumatology | date=2023-03-15 | volume=41 | issue=4 | pages=964–974 | issn=1593-098X | doi=10.55563/clinexprheumatol/tep3k5 | pmid=36995324 | s2cid=257836514 | doi-access=free }} |
| IgA nephropathy | Kidneys | IgA autoantibodies | Confirmed | 3.5 per 100,000 | last1=Gesualdo | first1=Loreto | last2=Di Leo | first2=Vincenzo | last3=Coppo | first3=Rosanna | title=The mucosal immune system and IgA nephropathy | journal=Seminars in Immunopathology | publisher=Springer Science and Business Media LLC | volume=43 | issue=5 | year=2021 | issn=1863-2297 | doi=10.1007/s00281-021-00871-y | pages=657–668 | pmid=34642783 | pmc=8551125 }} | ||||
| Membranous nephropathy | Kidneys | Anti-PLA2R antibodies | Confirmed | 10 per 100,000 | last1=Keri | first1=Krishna C | last2=Blumenthal | first2=Samuel | last3=Kulkarni | first3=Varsha | last4=Beck | first4=Laurence | last5=Chongkrairatanakul | first5=Tepsiri | title=Primary membranous nephropathy: comprehensive review and historical perspective | journal=Postgraduate Medical Journal | publisher=Oxford University Press (OUP) | volume=95 | issue=1119 | date=2019-01-01 | issn=0032-5473 | doi=10.1136/postgradmedj-2018-135729 | pages=23–31 | pmid=30683678 | s2cid=59275094 }} |
| Lupus nephritis | Kidneys | Anti-dsDNA, Anti-Sm, Anti-nuclear antibodies | Confirmed | Up to 60% of those with Lupus | |||||||||||||||||||||
| Interstitial nephritis | Kidneys | Various autoantibodies | Probable | Varies widely, often drug-induced | |||||||||||||||||||||
| Interstitial cystitis | Bladder | Anti-urothelial and anti-nuclear antibodies | Probable | 100-450 per 100,000 women, less common in men | |||||||||||||||||||||
| Primary sclerosing cholangitis | Bile ducts, can affect gallbladder | P-ANCA, Anti Smooth Muscle Antibodies (ASMA) | Confirmed | 1 per 100,000 |
Nervous system
| Autoimmune disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. |
|---|---|---|---|---|---|
| Acute disseminated encephalomyelitis | Central nervous system | Unknown | Confirmed | 0.8 per 100,000 | |
| Acute motor axonal neuropathy | Peripheral nerves | Anti-GM1 | Confirmed | Part of Guillain-Barré syndrome prevalence | |
| Anti-NMDA receptor encephalitis | Brain | Anti-NMDA receptor | Confirmed | 1.5 per million | |
| Autoimmune encephalitis | Brain | Various, depending on subtype (e.g., NMDA receptor antibodies, LGI1 antibodies) | Confirmed | Rare | |
| Balo concentric sclerosis | Central nervous system | Unknown | Probable | Rare | |
| Bickerstaff's encephalitis | Brain | Anti-GQ1b | Confirmed | Rare | |
| Chronic inflammatory demyelinating polyneuropathy | Peripheral nerves | Various, including anti-MAG | Confirmed | 1-2 per 100,000 | |
| Guillain-Barré syndrome | Peripheral nerves | Various, including anti-GM1, anti-GD1a | Confirmed | 1-2 per 100,000 | |
| Hashimoto's encephalopathy | Brain | Anti-thyroid (TPO, Tg) | Probable | Rare | |
| Idiopathic inflammatory demyelinating diseases | Central nervous system | Varies | Probable | Varies by specific disease | |
| Lambert–Eaton myasthenic syndrome | Neuromuscular junction (affecting both CNS and PNS) | Anti-VGCC | Confirmed | 0.5-2 per million | |
| Multiple sclerosis | Central nervous system | Unknown, but Oligoclonal bands often present in CSF | Confirmed | 90 per 100,000 | |
| Myasthenia gravis | Neuromuscular junction (affecting both CNS and PNS) | Anti-AChR, anti-MuSK | Confirmed | 20 per 100,000 | |
| Neuromyelitis optica (Devic's disease)/NMOSD | Optic nerves and spinal cord | AQP4-IgG (NMO-IgG) | Confirmed | 0.5 - 4 per 100,000 | |
| Restless legs syndrome | Central nervous system (thought to involve dopaminergic pathways) | Unknown | Uncertain | 5-15% (more common in older adults) | |
| Stiff-person syndrome | Central nervous system | Anti-GAD, anti-amphiphysin | Confirmed | Rare | |
| Sydenham's chorea | Brain | Anti-basal ganglia | Confirmed | Rare (linked to Group A streptococcal infection) | |
| Transverse myelitis | Spinal cord | Various, including anti-AQP4 | Probable | 1-8 per million | |
| Undifferentiated connective tissue disease (UCTD) | Various | ANA (antinuclear autoantibody) (HEp-2 cells) | Confirmed | 2 per 100,000 |
Endocrine system
| Autoimmune disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Addison's disease | Adrenal glands | 21-hydroxylase antibodies | Confirmed | 0.93-1.4 per 10,000 | last1=Saverino | first1=Serena | last2=Falorni | first2=Alberto | title=Autoimmune Addison's disease | journal=Best Practice & Research Clinical Endocrinology & Metabolism | publisher=Elsevier BV | volume=34 | issue=1 | year=2020 | issn=1521-690X | doi=10.1016/j.beem.2020.101379 | article-number=101379 | pmid=32063488 }} | ||||||||||||||||||||
| Autoimmune oophoritis | Ovaries | Anti-ovarian antibodies | Probable | Rare | last1=Levit | first1=Elizabeth | last2=Singh | first2=Bhuchitra | last3=Nylander | first3=Elisabeth | last4=Segars | first4=James H. | title=A Systematic Review of Autoimmune Oophoritis Therapies | journal=Reproductive Sciences | publisher=Springer Science and Business Media LLC | date=2023-07-27 | volume=31 | issue=1 | pages=1–16 | issn=1933-7191 | doi=10.1007/s43032-023-01299-5 | pmid=37500976 | s2cid=260246899 }} | |||||||||||||||
| Autoimmune orchitis | Testes | Anti-sperm antibodies | Probable | Rare | last1=Silva | first1=C.A. | last2=Cocuzza | first2=M. | last3=Carvalho | first3=J.F. | last4=Bonfá | first4=E. | title=Diagnosis and classification of autoimmune orchitis | journal=Autoimmunity Reviews | publisher=Elsevier BV | volume=13 | issue=4–5 | year=2014 | issn=1568-9972 | doi=10.1016/j.autrev.2014.01.024 | pages=431–434 | pmid=24424181 }} | ||||||||||||||||
| Autoimmune pancreatitis | Pancreas | IgG4, Anti-CA2 antibodies | Confirmed | 0.82-1.3 per 100,000 | last1=Nista | first1=Enrico Celestino | last2=De Lucia | first2=Sara Sofia | last3=Manilla | first3=Vittoria | last4=Schepis | first4=Tommaso | last5=Pellegrino | first5=Antonio | last6=Ojetti | first6=Veronica | last7=Pignataro | first7=Giulia | last8=Zileri dal Verme | first8=Lorenzo | last9=Franceschi | first9=Francesco | last10=Gasbarrini | first10=Antonio | last11=Candelli | first11=Marcello | title=Autoimmune Pancreatitis: From Pathogenesis to Treatment | journal=International Journal of Molecular Sciences | publisher=MDPI AG | volume=23 | issue=20 | date=2022-10-21 | issn=1422-0067 | doi=10.3390/ijms232012667 | article-number=12667 | pmid=36293522 | pmc=9604056 | doi-access=free }} |
| Autoimmune polyendocrine syndrome type 1 (APS1) | Multiple endocrine organs | Various autoantibodies depending on the organs affected | Confirmed | 1 in 100,000 to 200,000 | last1=Bjørklund | first1=Geir | last2=Pivin | first2=Maksim | last3=Hangan | first3=Tony | last4=Yurkovskaya | first4=Oksana | last5=Pivina | first5=Lyudmila | title=Autoimmune polyendocrine syndrome type 1: Clinical manifestations, pathogenetic features, and management approach | journal=Autoimmunity Reviews | publisher=Elsevier BV | volume=21 | issue=8 | year=2022 | issn=1568-9972 | doi=10.1016/j.autrev.2022.103135 | article-number=103135 | pmid=35690244 }} | ||||||||||||||
| Autoimmune polyendocrine syndrome type 2 (APS2) | Multiple endocrine organs | Various autoantibodies depending on the organs affected | Confirmed | 1 in 20,000 | last1=Husebye | first1=Eystein S. | last2=Anderson | first2=Mark S. | last3=Kämpe | first3=Olle | title=Autoimmune Polyendocrine Syndromes | journal=New England Journal of Medicine | publisher=Massachusetts Medical Society | volume=378 | issue=12 | date=2018-03-22 | issn=0028-4793 | doi=10.1056/nejmra1713301 | pages=1132–1141 | pmid=29562162 | pmc=6007870 }} | |||||||||||||||||
| Autoimmune polyendocrine syndrome type 3 (APS3) | Multiple endocrine organs | Various autoantibodies depending on the organs affected | Confirmed | Rare | ||||||||||||||||||||||||||||||||||
| Diabetes mellitus type 1 | Pancreas | Anti-insulin, anti-IA-2, anti-GAD, anti-ZnT8 antibodies | Confirmed | 5 per 1,000 | last1=Rezaei | first1=Nima | last2=Bahreini | first2=Farbod | last3=Rayzan | first3=Elham | title=MicroRNAs and Diabetes Mellitus Type 1 | journal=Current Diabetes Reviews | publisher=Bentham Science Publishers Ltd. | volume=18 | issue=2 | year=2022 | pages=e021421191398 | issn=1573-3998 | doi=10.2174/1573399817666210215111201 | pmid=33588736 | s2cid=231938319 }} | |||||||||||||||||
| Endometriosis | Endometrium | Anti-endometrial antibodies | Probable | 6-10% of women of reproductive age | last1=Abramiuk | first1=Monika | last2=Grywalska | first2=Ewelina | last3=Małkowska | first3=Paulina | last4=Sierawska | first4=Olga | last5=Hrynkiewicz | first5=Rafał | last6=Niedźwiedzka-Rystwej | first6=Paulina | title=The Role of the Immune System in the Development of Endometriosis | journal=Cells | publisher=MDPI AG | volume=11 | issue=13 | date=2022-06-25 | issn=2073-4409 | doi=10.3390/cells11132028 | page=2028 | pmid=35805112 | pmc=9265783 | doi-access=free }} | ||||||||||
| Graves' disease | Thyroid gland | TSI, TPO, TG antibodies | Confirmed | 1.2% of the population | last1=Moshkelgosha | first1=Sajad | last2=So | first2=Po-Wah | last3=Diaz-Cano | first3=Salvador | last4=Banga | first4=J. | title=Preclinical Models of Graves' Disease and Associated Secondary Complications | journal=Current Pharmaceutical Design | publisher=Bentham Science Publishers Ltd. | volume=21 | issue=18 | date=2015-04-30 | issn=1381-6128 | doi=10.2174/1381612821666150316121945 | pages=2414–2421 | pmid=25777757 | url=https://figshare.com/articles/journal_contribution/1441209 }} | |||||||||||||||
| Hashimoto's thyroiditis | Thyroid gland | TPO, TG antibodies | Confirmed | 5% of the population | last1=Mikulska | first1=Aniceta A. | last2=Karaźniewicz-Łada | first2=Marta | last3=Filipowicz | first3=Dorota | last4=Ruchała | first4=Marek | last5=Główka | first5=Franciszek K. | title=Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management—An Overview | journal=International Journal of Molecular Sciences | publisher=MDPI AG | volume=23 | issue=12 | date=2022-06-13 | issn=1422-0067 | doi=10.3390/ijms23126580 | page=6580 | pmid=35743024 | pmc=9223845 | doi-access=free }} | ||||||||||||
| Ord's thyroiditis | Thyroid gland | TPO, TG antibodies | Confirmed | Rare | last1=Carlé | first1=Allan | last2=Pedersen | first2=Inge Bülow | last3=Knudsen | first3=Nils | last4=Perrild | first4=Hans | last5=Ovesen | first5=Lars | last6=Jørgensen | first6=Torben | last7=Laurberg | first7=Peter | title=Thyroid Volume in Hypothyroidism due to Autoimmune Disease Follows a Unimodal Distribution: Evidence against Primary Thyroid Atrophy and Autoimmune Thyroiditis Being Distinct Diseases | journal=The Journal of Clinical Endocrinology & Metabolism | publisher=The Endocrine Society | volume=94 | issue=3 | date=2009-03-01 | issn=0021-972X | doi=10.1210/jc.2008-1370 | pages=833–839 | pmid=19088156 | s2cid=8184654 }} |
Respiratory system
| Autoimmune disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Goodpasture syndrome | Confirmed | ||||||||||||||||||||||||||||||||||
| Eosinophilic granulomatosis with polyangiitis (EGPA) | Confirmed | ||||||||||||||||||||||||||||||||||
| Granulomatosis with polyangiitis (GPA) | Confirmed | ||||||||||||||||||||||||||||||||||
| Idiopathic pulmonary fibrosis | Lungs | None specific | Possible | 20 per 100,000 (men), 13 per 100,000 (women) | last1=Hoyne | first1=Gerard F | last2=Elliott | first2=Hannah | last3=Mutsaers | first3=Steven E | last4=Prêle | first4=Cecilia M | title=Idiopathic pulmonary fibrosis and a role for autoimmunity | journal=Immunology & Cell Biology | publisher=Wiley | volume=95 | issue=7 | date=2017-04-25 | issn=0818-9641 | doi=10.1038/icb.2017.22 | pages=577–583 | pmid=28356570 | s2cid=205152247 | url=https://researchonline.nd.edu.au/cgi/viewcontent.cgi?article=1177&context=health_article | url-access=subscription }} | ||||||||||
| Interstitial lung disease | Lungs | Depends on the subtype (e.g. Anti-Jo1 in Anti-synthetase syndrome) | Probable | 31.5 per 100,000 (men), 26.1 per 100,000 (women) | last1=Kadura | first1=Suha | last2=Raghu | first2=Ganesh | title=Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management | journal=European Respiratory Review | publisher=European Respiratory Society (ERS) | volume=30 | issue=160 | date=2021-06-23 | issn=0905-9180 | doi=10.1183/16000617.0011-2021 | page=210011 | pmid=34168062 | pmc=9489133 }} | ||||||||||||||||
| Pulmonary alveolar proteinosis | Lungs | Anti-GM-CSF antibodies | Confirmed | 6.2 per million | last1=Trapnell | first1=Bruce C. | last2=Nakata | first2=Koh | last3=Bonella | first3=Francesco | last4=Campo | first4=Ilaria | last5=Griese | first5=Matthias | last6=Hamilton | first6=John | last7=Wang | first7=Tisha | last8=Morgan | first8=Cliff | last9=Cottin | first9=Vincent | last10=McCarthy | first10=Cormac | title=Pulmonary alveolar proteinosis | journal=Nature Reviews Disease Primers | publisher=Springer Science and Business Media LLC | volume=5 | issue=1 | date=2019-03-07 | issn=2056-676X | doi=10.1038/s41572-019-0066-3 | page=16 | pmid=30846703 | s2cid=73484878 }} |
| Rheumatoid lung disease | Lungs | Rheumatoid factor, Anti-CCP antibodies | Confirmed | Part of RA prevalence (about 1%) | last1=Akiyama | first1=Mitsuhiro | last2=Kaneko | first2=Yuko | title=Pathogenesis, clinical features, and treatment strategy for rheumatoid arthritis-associated interstitial lung disease | journal=Autoimmunity Reviews | publisher=Elsevier BV | volume=21 | issue=5 | year=2022 | issn=1568-9972 | doi=10.1016/j.autrev.2022.103056 | article-number=103056 | pmid=35121155 | s2cid=246496520 | doi-access=free }} | |||||||||||||||
| Sarcoidosis | Lungs and other organs | None specific | Confirmed | 10 - 40 per 100,000 | last1=Brito-Zerón | first1=Pilar | last2=Pérez-Álvarez | first2=Roberto | last3=Ramos-Casals | first3=Manuel | title=Sarcoidosis | journal=Medicina Clínica | publisher=Elsevier BV | volume=159 | issue=4 | year=2022 | issn=0025-7753 | doi=10.1016/j.medcli.2022.03.009 | pages=195–204 | pmid=35680449 | language=es}} |
Blood
| Autoimmune disease | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Autoimmune hemolytic anemia | Anti-red blood cell antibodies | Confirmed | 1-3 per 100,000 | last1=Scheckel | first1=Caleb J. | last2=Go | first2=Ronald S. | title=Autoimmune Hemolytic Anemia: Diagnosis and Differential Diagnosis | journal=Hematology/Oncology Clinics of North America | publisher=Elsevier BV | volume=36 | issue=2 | year=2022 | issn=0889-8588 | doi=10.1016/j.hoc.2021.12.001 | pages=315–324 | pmid=35282951 | s2cid=247428832 }} | ||||||
| Immune thrombocytopenia | Anti-platelet antibodies | Confirmed | 3.3 per 100,000 (adults), 50 per 100,000 (children) | last1=Audia | first1=Sylvain | last2=Mahévas | first2=Matthieu | last3=Samson | first3=Maxime | last4=Godeau | first4=Bertrand | last5=Bonnotte | first5=Bernard | title=Pathogenesis of immune thrombocytopenia | journal=Autoimmunity Reviews | publisher=Elsevier BV | volume=16 | issue=6 | year=2017 | issn=1568-9972 | doi=10.1016/j.autrev.2017.04.012 | pages=620–632 | pmid=28428120 | url=https://hal.science/hal-04242234 }} |
| Thrombotic thrombocytopenic purpura | ADAMTS13 autoantibodies | Confirmed | 1-2 per million | last=Sadler | first=J. Evan | title=Pathophysiology of thrombotic thrombocytopenic purpura | journal=Blood | publisher=American Society of Hematology | volume=130 | issue=10 | date=2017-09-07 | issn=0006-4971 | doi=10.1182/blood-2017-04-636431 | pages=1181–1188 | pmid=28768626 | pmc=5606001 }} | ||||||||
| Antiphospholipid syndrome | Antiphospholipid antibodies | Confirmed | 40-50 per 100,000 | last=Sammaritano | first=Lisa R. | title=Antiphospholipid syndrome | journal=Best Practice & Research Clinical Rheumatology | publisher=Elsevier BV | volume=34 | issue=1 | year=2020 | issn=1521-6942 | doi=10.1016/j.berh.2019.101463 | article-number=101463 | pmid=31866276 | s2cid=209447261 }} | ||||||||
| Paroxysmal nocturnal hemoglobinuria | None specific, mutation causes self-cells to become susceptible to attack | Possible | 1-2 per million | last=Brodsky | first=Robert A. | title=How I treat paroxysmal nocturnal hemoglobinuria | journal=Blood | publisher=American Society of Hematology | volume=137 | issue=10 | date=2021-03-11 | issn=0006-4971 | doi=10.1182/blood.2019003812 | pages=1304–1309 | pmid=33512400 | pmc=7955407 }} |
Reproductive system
The reproductive system is responsible for the production and regulation of sex hormones, the formation of germ cells, and the nurturing of fertilized eggs. In women, it includes structures such as ovaries, fallopian tubes, a uterus, and a vagina, while in men, it includes testes, vas deferens, seminal vesicles, prostate, and the penis. Autoimmune diseases of the reproductive system can affect both male and female fertility and reproductive health.
| Autoimmune disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Autoimmune orchitis | Testes | Anti-sperm antibodies | Probable | Not well established | date=November 2023}} | ||||||||||||||||||
| Autoimmune oophoritis | Ovaries | Anti-ovarian antibodies | Probable | Not well established | |||||||||||||||||||
| Endometriosis | Uterus, ovaries, and pelvic tissue | Various, including anti-endometrial antibodies | Probable | Approx. 10% of women of reproductive age | last1=Bulletti | first1=C. | last2=Coccia | first2=M. E. | last3=Battistoni | first3=S. | last4=Borini | first4=A. | title=Endometriosis and infertility | journal=Journal of Assisted Reproduction and Genetics | publisher=Springer Science and Business Media LLC | volume=27 | issue=8 | date=2010-08-01 | issn=1058-0468 | doi=10.1007/s10815-010-9436-1 | pages=441–447 | pmid=20574791 | pmc=2941592 }} |
| Premature ovarian failure | Ovaries | Anti-ovarian antibodies, Anti-adrenal antibodies | Confirmed | 1% of women under 40 years | last=Nelson | first=Lawrence M. | title=Primary Ovarian Insufficiency | journal=New England Journal of Medicine | publisher=Massachusetts Medical Society | volume=360 | issue=6 | date=2009-02-05 | issn=0028-4793 | doi=10.1056/NEJMcp0808697 | pages=606–614 | pmid=19196677 | pmc=2762081 }} |
Eyes
| Autoimmune disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disease | Prevalence rate (US) | Cit. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Autoimmune retinopathy | Retina | Various | Confirmed | last1=Dutta Majumder | first1=Parthopratim | last2=Marchese | first2=Alessandro | last3=Pichi | first3=Francesco | last4=Garg | first4=Itika | last5=Agarwal | first5=Aniruddha | title=An update on autoimmune retinopathy | journal=Indian Journal of Ophthalmology | publisher=Medknow | volume=68 | issue=9 | year=2020 | pages=1829–1837 | issn=0301-4738 | doi=10.4103/ijo.ijo_786_20 | pmid=32823399 | pmc=7690499 | doi-access=free }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Autoimmune uveitis | Uvea | Various | Confirmed | last1=Horai | first1=Reiko | last2=Caspi | first2=Rachel R. | title=Microbiome and Autoimmune Uveitis | journal=Frontiers in Immunology | publisher=Frontiers Media SA | volume=10 | date=2019-02-19 | issn=1664-3224 | doi=10.3389/fimmu.2019.00232 | page=232 | pmid=30837991 | pmc=6389708 | doi-access=free }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cogan syndrome | Inner ear and eye | None specific | Probable | last1=Espinoza | first1=Gabriela Mabel | last2=Wheeler | first2=Joseph | last3=Temprano | first3=Katherine K. | last4=Keller | first4=Angela Prost | title=Cogan's Syndrome: Clinical Presentations and Update on Treatment | journal=Current Allergy and Asthma Reports | publisher=Springer Science and Business Media LLC | volume=20 | issue=9 | date=2020-06-16 | issn=1529-7322 | doi=10.1007/s11882-020-00945-1 | page=46 | pmid=32548646 | s2cid=219692073 }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Graves' ophthalmopathy | Eye muscles and connective tissue | TSH receptor antibodies | Confirmed | last1=González-García | first1=Andrés | last2=Sales-Sanz | first2=Marco | title=Tratamiento de la oftalmopatía de Graves | journal=Medicina Clínica | publisher=Elsevier BV | volume=156 | issue=4 | year=2021 | issn=0025-7753 | doi=10.1016/j.medcli.2020.07.031 | pages=180–186 | pmid=33069387 | s2cid=225173294 | language=es}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Intermediate uveitis | Uvea (pars plana) | Various | Probable | last1=Teo | first1=Andrea York Tiang | last2=Betzler | first2=Bjorn Kaijun | last3=Hua | first3=Keith Low Qie | last4=Chen | first4=Elizabeth Jiahui | last5=Gupta | first5=Vishali | last6=Agrawal | first6=Rupesh | title=Intermediate Uveitis: A Review | journal=Ocular Immunology and Inflammation | publisher=Informa UK Limited | volume=31 | issue=5 | date=2022-06-27 | issn=0927-3948 | doi=10.1080/09273948.2022.2070503 | pages=1041–1060 | pmid=35759636 | s2cid=250090138 }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ligneous conjunctivitis | Conjunctiva | Plasminogen deficiency | Possible | Rare | last1=Tu | first1=Yufei | last2=Gonzalez-Gronow | first2=Mario | last3=Kolomeyer | first3=Anton M. | last4=Cohen | first4=Alice | last5=Pruzon | first5=Joanna | last6=Milman | first6=Tatyana | last7=Chu | first7=David S. | title=Adult-Onset Ligneous Conjunctivitis with Detection of a Novel Plasminogen Gene Mutation and Anti-Plasminogen IgA Antibody: A Clinicopathologic Study and Review of Literature | journal=Seminars in Ophthalmology | publisher=Informa UK Limited | date=2015-02-12 | volume=31 | issue=6 | issn=0882-0538 | doi=10.3109/08820538.2015.1005319 | pages=526–531 | pmid=25674820 | s2cid=45834939 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Mooren's ulcer | Cornea | None specific | Probable | Rare | last1=He | first1=Na | last2=Song | first2=Wei | last3=Gao | first3=Ying | title=Treatment of Mooren's ulcer coexisting with a pterygium using an intrastromal lenticule obtained from small-incision lenticule extraction: case report and literature review | journal=Journal of International Medical Research | publisher=SAGE Publications | volume=49 | issue=6 | year=2021 | issn=0300-0605 | doi=10.1177/03000605211020246 | page=030006052110202 | pmid=34130538 | pmc=8212381 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Neuromyelitis optica | Optic nerve and spinal cord | Anti-AQP4 | Confirmed | last1=Wingerchuk | first1=Dean M. | last2=Banwell | first2=Brenda | last3=Bennett | first3=Jeffrey L. | last4=Cabre | first4=Philippe | last5=Carroll | first5=William | last6=Chitnis | first6=Tanuja | last7=de Seze | first7=Jérôme | last8=Fujihara | first8=Kazuo | last9=Greenberg | first9=Benjamin | last10=Jacob | first10=Anu | last11=Jarius | first11=Sven | last12=Lana-Peixoto | first12=Marco | last13=Levy | first13=Michael | last14=Simon | first14=Jack H. | last15=Tenembaum | first15=Silvia | last16=Traboulsee | first16=Anthony L. | last17=Waters | first17=Patrick | last18=Wellik | first18=Kay E. | last19=Weinshenker | first19=Brian G. | title=International consensus diagnostic criteria for neuromyelitis optica spectrum disorders | journal=Neurology | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=85 | issue=2 | date=2015-06-19 | issn=0028-3878 | doi=10.1212/wnl.0000000000001729 | pages=177–189 | pmid=26092914 | pmc=4515040 | s2cid=5932243 }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Opsoclonus myoclonus syndrome | Central nervous system, eye movement control | Anti-neuronal antibodies | Possible | last1=Bhatia | first1=Poonam | last2=Heim | first2=Jennifer | last3=Cornejo | first3=Patricia | last4=Kane | first4=Lauren | last5=Santiago | first5=Jason | last6=Kruer | first6=Michael C. | title=Opsoclonus–myoclonus–ataxia syndrome in children | journal=Journal of Neurology | publisher=Springer Science and Business Media LLC | volume=269 | issue=2 | date=2021-03-29 | issn=0340-5354 | doi=10.1007/s00415-021-10536-3 | pages=750–757 | pmid=33779841 | s2cid=232387732 }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Optic neuritis | Optic nerve | Various | Confirmed | last1=Petzold | first1=Axel | last2=Fraser | first2=Clare L | last3=Abegg | first3=Mathias | last4=Alroughani | first4=Raed | last5=Alshowaeir | first5=Daniah | last6=Alvarenga | first6=Regina | last7=Andris | first7=Cécile | last8=Asgari | first8=Nasrin | last9=Barnett | first9=Yael | last10=Battistella | first10=Roberto | last11=Behbehani | first11=Raed | last12=Berger | first12=Thomas | last13=Bikbov | first13=Mukharram M | last14=Biotti | first14=Damien | last15=Biousse | first15=Valerie | last16=Boschi | first16=Antonella | last17=Brazdil | first17=Milan | last18=Brezhnev | first18=Andrei | last19=Calabresi | first19=Peter A | last20=Cordonnier | first20=Monique | last21=Costello | first21=Fiona | last22=Cruz | first22=Franz M | last23=Cunha | first23=Leonardo Provetti | last24=Daoudi | first24=Smail | last25=Deschamps | first25=Romain | last26=de Seze | first26=Jerome | last27=Diem | first27=Ricarda | last28=Etemadifar | first28=Masoud | last29=Flores-Rivera | first29=Jose | last30=Fonseca | first30=Pedro | last31=Frederiksen | first31=Jette | last32=Frohman | first32=Elliot | last33=Frohman | first33=Teresa | last34=Tilikete | first34=Caroline Froment | last35=Fujihara | first35=Kazuo | last36=Gálvez | first36=Alberto | last37=Gouider | first37=Riadh | last38=Gracia | first38=Fernando | last39=Grigoriadis | first39=Nikolaos | last40=Guajardo | first40=José M | last41=Habek | first41=Mario | last42=Hawlina | first42=Marko | last43=Martínez-Lapiscina | first43=Elena H | last44=Hooker | first44=Juzar | last45=Hor | first45=Jyh Yung | last46=Howlett | first46=William | last47=Huang-Link | first47=Yumin | last48=Idrissova | first48=Zhannat | last49=Illes | first49=Zsolt | last50=Jancic | first50=Jasna | last51=Jindahra | first51=Panitha | last52=Karussis | first52=Dimitrios | last53=Kerty | first53=Emilia | last54=Kim | first54=Ho Jin | last55=Lagrèze | first55=Wolf | last56=Leocani | first56=Letizia | last57=Levin | first57=Netta | last58=Liskova | first58=Petra | last59=Liu | first59=Yaou | last60=Maiga | first60=Youssoufa | last61=Marignier | first61=Romain | last62=McGuigan | first62=Chris | last63=Meira | first63=Dália | last64=Merle | first64=Harold | last65=Monteiro | first65=Mário L R | last66=Moodley | first66=Anand | last67=Moura | first67=Frederico | last68=Muñoz | first68=Silvia | last69=Mustafa | first69=Sharik | last70=Nakashima | first70=Ichiro | last71=Noval | first71=Susana | last72=Oehninger | first72=Carlos | last73=Ogun | first73=Olufunmilola | last74=Omoti | first74=Afekhide | last75=Pandit | first75=Lekha | last76=Paul | first76=Friedemann | last77=Rebolleda | first77=Gema | last78=Reddel | first78=Stephen | last79=Rejdak | first79=Konrad | last80=Rejdak | first80=Robert | last81=Rodriguez-Morales | first81=Alfonso J | last82=Rougier | first82=Marie-Bénédicte | last83=Sa | first83=Maria Jose | last84=Sanchez-Dalmau | first84=Bernardo | last85=Saylor | first85=Deanna | last86=Shatriah | first86=Ismail | last87=Siva | first87=Aksel | last88=Stiebel-Kalish | first88=Hadas | last89=Szatmary | first89=Gabriella | last90=Ta | first90=Linh | last91=Tenembaum | first91=Silvia | last92=Tran | first92=Huy | last93=Trufanov | first93=Yevgen | last94=van Pesch | first94=Vincent | last95=Wang | first95=An-Guor | last96=Wattjes | first96=Mike P | last97=Willoughby | first97=Ernest | last98=Zakaria | first98=Magd | last99=Zvornicanin | first99=Jasmin | display-authors=1 | last100=Balcer | first100=Laura | last101=Plant | first101=Gordon T | title=Diagnosis and classification of optic neuritis | journal=The Lancet Neurology | publisher=Elsevier BV | volume=21 | issue=12 | year=2022 | issn=1474-4422 | doi=10.1016/s1474-4422(22)00200-9 | pages=1120–1134 | pmid=36179757 | s2cid=252564095 | url=https://discovery.ucl.ac.uk/id/eprint/10156457/ }} | |
| Scleritis | Sclera | Various | Possible | last1=Promelle | first1=Veronique | last2=Goeb | first2=Vincent | last3=Gueudry | first3=Julie | title=Rheumatoid Arthritis Associated Episcleritis and Scleritis: An Update on Treatment Perspectives | journal=Journal of Clinical Medicine | publisher=MDPI AG | volume=10 | issue=10 | date=2021-05-14 | issn=2077-0383 | doi=10.3390/jcm10102118 | page=2118 | pmid=34068884 | pmc=8156434 | doi-access=free }} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Susac's syndrome | Retina, cochlea, and brain | None specific | Probable | last1=Pereira | first1=Sara | last2=Vieira | first2=Bruna | last3=Maio | first3=Tiago | last4=Moreira | first4=Jorge | last5=Sampaio | first5=Filipa | title=Susac's Syndrome: An Updated Review | journal=Neuro-Ophthalmology | publisher=Informa UK Limited | volume=44 | issue=6 | date=2020-05-01 | issn=0165-8107 | doi=10.1080/01658107.2020.1748062 | pages=355–360 | pmid=33408428 | pmc=7746245 }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sympathetic ophthalmia | Uveal tract | Various | Probable | Rare | last1=Agrawal | first1=Deepshikha | last2=Parchand | first2=Swapnil | last3=Ayyadurai | first3=Nikitha | last4=Agarwal | first4=Aniruddha | last5=Gangwe | first5=Anil | last6=Behera | first6=Shashwat | last7=Bhatia | first7=Priyavat | last8=Mulkutkar | first8=Samyak | last9=Barwar | first9=Gulshan | last10=Singh | first10=Ramandeep | last11=Sen | first11=Alok | last12=Agarwal | first12=Manisha | title=Sympathetic ophthalmia: A comprehensive update | journal=Indian Journal of Ophthalmology | publisher=Medknow | volume=70 | issue=6 | year=2022 | pages=1931–1944 | issn=0301-4738 | doi=10.4103/ijo.ijo_2363_21 | pmid=35647958 | pmc=9359263 | doi-access=free }} | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tolosa–Hunt syndrome | Orbit | None specific | Uncertain | Rare | last1=Badakere | first1=Akshay | last2=Patil- Chhablani | first2=Preeti | title=Orbital Apex Syndrome: A Review | journal=Eye and Brain | publisher=Informa UK Limited | volume=11 | year=2019 | issn=1179-2744 | doi=10.2147/eb.s180190 | pages=63–72 | pmid=31849556 | pmc=6913296 | doi-access=free }} |
Musculoskeletal system
These autoimmune diseases are primarily associated with the muscles, joints and neuromuscular function.
| Autoimmune disease | Primary organ/body part affected | Autoantibodies | Acceptance as an autoimmune disorder | Prevalence rate (US) | Cit. | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dermatomyositis | Confirmed | |||||||||||||||||||||||
| Fibromyalgia | Musculoskeletal system, pain perception | None specific | Possible | last1=Siracusa | first1=Rosalba | last2=Paola | first2=Rosanna Di | last3=Cuzzocrea | first3=Salvatore | last4=Impellizzeri | first4=Daniela | title=Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update | journal=International Journal of Molecular Sciences | publisher=MDPI AG | volume=22 | issue=8 | date=2021-04-09 | issn=1422-0067 | doi=10.3390/ijms22083891 | page=3891 | pmid=33918736 | pmc=8068842 | doi-access=free }} | |
| Inclusion body myositis | Proximal and distal muscles | None specific | Probable | last=Greenberg | first=Steven A. | title=Inclusion body myositis: clinical features and pathogenesis | journal=Nature Reviews Rheumatology | publisher=Springer Science and Business Media LLC | volume=15 | issue=5 | date=2019-03-05 | issn=1759-4790 | doi=10.1038/s41584-019-0186-x | pages=257–272 | pmid=30837708 | s2cid=71146208 }} | ||||||||
| Myositis | Skeletal muscles | Various, depends on subtype | Confirmed | last1=Betteridge | first1=Z. | last2=McHugh | first2=N. | title=Myositis-specific autoantibodies: an important tool to support diagnosis of myositis | journal=Journal of Internal Medicine | publisher=Wiley | volume=280 | issue=1 | date=2015-11-25 | issn=0954-6820 | doi=10.1111/joim.12451 | pages=8–23 | pmid=26602539 | s2cid=41157692 | doi-access=free }} | |||||
| Myasthenia gravis | Voluntary muscles, neuromuscular junctions | Anti-acetylcholine receptor, Anti-MuSK | Confirmed | last1=Gilhus | first1=Nils Erik | last2=Verschuuren | first2=Jan J | title=Myasthenia gravis: subgroup classification and therapeutic strategies | journal=The Lancet Neurology | publisher=Elsevier BV | volume=14 | issue=10 | year=2015 | issn=1474-4422 | doi=10.1016/s1474-4422(15)00145-3 | pages=1023–1036 | pmid=26376969 | s2cid=19615369 }} | ||||||
| Neuromyotonia | Peripheral nerves affecting muscle control | Anti-voltage-gated potassium channels | Probable | last1=Comperat | first1=Louis | last2=Pegat | first2=Antoine | last3=Honnorat | first3=Jérôme | last4=Joubert | first4=Bastien | title=Autoimmune neuromyotonia | journal=Current Opinion in Neurology | publisher=Ovid Technologies (Wolters Kluwer Health) | volume=35 | issue=5 | date=2022-08-19 | issn=1350-7540 | doi=10.1097/wco.0000000000001104 | pages=597–603 | pmid=35989569 | s2cid=251720232 }} | ||
| Paraneoplastic cerebellar degeneration | Central nervous system, cerebellum | Anti-Yo, Anti-Hu, Anti-Ri, others | Confirmed | last1=Loehrer | first1=Philipp Alexander | last2=Zieger | first2=Lara | last3=Simon | first3=Ole J. | title=Update on Paraneoplastic Cerebellar Degeneration | journal=Brain Sciences | publisher=MDPI AG | volume=11 | issue=11 | date=2021-10-26 | issn=2076-3425 | doi=10.3390/brainsci11111414 | page=1414 | pmid=34827413 | pmc=8615604 | doi-access=free }} | |||
| Rheumatoid arthritis | Big and small joints of extremities, temporomandibular joints | Citrullinated proteins | Confirmed | 0.5 - 1% | ||||||||||||||||||||
| Polymyositis | Proximal skeletal muscles | Anti-Jo-1, Anti-SRP, others | Confirmed | last1=Findlay | first1=Andrew R. | last2=Goyal | first2=Namita A. | last3=Mozaffar | first3=Tahseen | title=An overview of polymyositis and dermatomyositis | journal=Muscle & Nerve | publisher=Wiley | volume=51 | issue=5 | date=2015-04-20 | issn=0148-639X | doi=10.1002/mus.24566 | pages=638–656 | pmid=25641317 | s2cid=206296273 | doi-access=free }} |
Autoimmune comorbidities
This list includes conditions that are not diseases, but symptoms or syndromes common to autoimmune disease.
- Chronic fatigue syndrome
- Complex regional pain syndrome
- Eosinophilic esophagitis
- Gastritis
- POEMS syndrome
- Raynaud's phenomenon
- Primary immunodeficiency
- Pyoderma gangrenosum
Non-autoimmune
At this time, there is not sufficient evidence to indicate that the diseases in the following table are caused by autoimmunity. This section is included because some of these conditions are immune-related but frequently confused with autoimmune diseases. Others are conditions that have been historically speculated as autoimmune due to overlapping symptoms like inflammation, but have been reclassified or excluded based on current research.
| Disease | Reason not believed to be autoimmune | Cit. | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Agammaglobulinemia | An immune system disorder but not an autoimmune disease. | ||||||||||
| Amyloidosis | No consistent evidence of association with autoimmunity. | ||||||||||
| Amyotrophic lateral sclerosis | No consistent evidence of association with autoimmunity. | ||||||||||
| Anti-tubular basement membrane nephritis | No consistent evidence of association with autoimmunity. | ||||||||||
| Atopic allergy | A hypersensitivity. | ||||||||||
| Atopic dermatitis | A hypersensitivity. | ||||||||||
| Autism | No consistent evidence of association with maternal autoimmunity. | ||||||||||
| Blau syndrome | Overlaps both sarcoidosis and granuloma annulare. No evidence of association with autoimmunity. | ||||||||||
| Cancer | No consistent evidence of association with autoimmunity. | ||||||||||
| Castleman's disease | An immune system disorder but not an autoimmune disease. | ||||||||||
| Chagas disease | No consistent evidence of association with autoimmunity. | ||||||||||
| Chronic obstructive pulmonary disease | No consistent evidence of association with autoimmunity. | vauthors=Agustí A, MacNee W, Donaldson K, Cosio M | title = Hypothesis: does COPD have an autoimmune component? | journal = Thorax | volume = 58 | issue = 10 | pages = 832–834 | year = 2003 | pmid = 14514931 | pmc = 1746486 | doi = 10.1136/thorax.58.10.832 }} |
| Chronic recurrent multifocal osteomyelitis | LPIN2, D18S60. Synonyms: Majeed syndrome. | ||||||||||
| Complement component 2 deficiency | Possibly symptomatic of autoimmune diseases, but not a disease. | ||||||||||
| Congenital heart block | May be related to autoimmune activity in the mother. | ||||||||||
| Contact dermatitis | A hypersensitivity. | ||||||||||
| Cushing's syndrome | No consistent evidence of association with autoimmunity. | ||||||||||
| Cutaneous leukocytoclastic angiitis | No consistent evidence of association with autoimmunity. | ||||||||||
| Dego's disease | No consistent evidence of association with autoimmunity. | ||||||||||
| Eosinophilic gastroenteritis | Possibly a hypersensitivity. | ||||||||||
| Eosinophilic pneumonia | A class of diseases, some of which may be autoimmune. | ||||||||||
| Erythroblastosis fetalis | Mother's immune system attacks fetus. An immune system disorder but not autoimmune. | ||||||||||
| Fibrodysplasia ossificans progressiva | Possibly an immune system disorder but not autoimmune. | ||||||||||
| Gastrointestinal pemphigoid | No consistent evidence of association with autoimmunity. | ||||||||||
| Hypogammaglobulinemia | An immune system disorder but not autoimmune. | ||||||||||
| Idiopathic giant-cell myocarditis | No consistent evidence of autoimmune cause though the disease has been found comorbid with other autoimmune diseases. | ||||||||||
| Idiopathic pulmonary fibrosis | Autoantibodies: SFTPA1, SFTPA2, TERT, and TERC. | ||||||||||
| IgA nephropathy | An immune system disorder but not an autoimmune disease. | ||||||||||
| IPEX syndrome | A genetic mutation in FOXP3 that leads to autoimmune diseases, but not an autoimmune disorder itself. | ||||||||||
| Ligneous conjunctivitis | No consistent evidence of association with autoimmunity. | ||||||||||
| Majeed syndrome | No consistent evidence of association with autoimmunity. | ||||||||||
| Narcolepsy | No evidence of association with autoimmunity. Research not reproducible. | vauthors=Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong SC, Hong SS, Honda Y, Honda M, Högl B, Longstreth WT, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erhardt C, Hesla PE, Poli F, Frauscher B, Jeong JH, Lee SP, Ton TG, Kvale M, Kolesar L, Dobrovolná M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok PY, Risch N, Mignot E | title = Narcolepsy is strongly associated with the TCR alpha locus | journal = Nature Genetics | volume = 41 | issue = 6 | pages = 708–11 | date = June 2009 | pmid = 19412176 | pmc = 2803042 | doi = 10.1038/ng.372}} |
| Rasmussen's encephalitis | No consistent evidence of association with autoimmunity. | ||||||||||
| Schizophrenia | No consistent evidence of association with autoimmunity. | ||||||||||
| Serum sickness | A hypersensitivity. | ||||||||||
| Spondyloarthropathy | No consistent evidence of association with autoimmunity. | ||||||||||
| Sweet's syndrome | No consistent evidence of association with autoimmunity. | ||||||||||
| Takayasu's arteritis | No consistent evidence of association with autoimmunity. | ||||||||||
| Undifferentiated spondyloarthropathy |
Notes
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