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LE cell

Type of macrophage

LE cell

Type of macrophage

Microphotograph of a macrophage that has phagocytized a lymphocyte (LE cell). May Grünwald Giemsa stain.

A lupus erythematosus cell (LE cell), also known as Hargraves cell, is a neutrophil or macrophage that has phagocytized (engulfed) the denatured nuclear material of another cell. The denatured material is an absorbed hematoxylin body (also called an LE body).

They are a characteristic of lupus erythematosus,{{cite web

The LE cell was discovered in bone marrow in 1948 by Malcolm McCallum Hargraves (1903–1982), a physician and practicing histologist at the Mayo Clinic*.* Hargraves may have gained priority by suppressing a publication draft of John R. Haserick, who credits Dorothy Sundberg, chief hematologist at the University of Minnesota Hospitals, with first identifying LE cells.

Classically, the LE cell is analyzed microscopically, but it is also possible to investigate this phenomenon by flow cytometry.

LE cells shouldn't be confused with Tart cells which have engulfed nuclear material, but with a visible chromatin rather than homogeneous appearance.

References

References

  1. "Medical Definition of LE CELL".
  2. [http://www.similima.com/pathology/path11.html similima.com > Autoimmunity] {{webarchive. link. (2011-07-27 Muhammed Muneer. Retrieved March 2011)
  3. Cheesbrough, Monica. (2000-10-26). "District Laboratory Practice in Tropical Countries". Cambridge University Press.
  4. Hargraves M, Richmond H, Morton R. ''Presentation of two bone marrow components, the tart cell and the LE cell.'' Mayo Clin Proc 1948;27:25–28.
  5. [https://www.derm101.com/dpc-archive/april-june-2000-volume-6-no-2/dpc0602a20-discovery-of-the-le-factor/ Discovery of the LE factor] ''Dermatopathology: Practical & Conceptual'' {{webarchive. link. (5 September 2019)
  6. Böhm, Ingrid. (1 January 2004). "Flow Cytometric Analysis of the LE Cell Phenomenon". Autoimmunity.
  7. (2015). "Diagnostic Cytopathology Board Review and Self-Assessment". Springer, New York, NY.
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