Surf Wiki
Save to docs
general/1-4-naphthoquinones

From Surf Wiki (app.surf) — the open knowledge base

Lapachol

Lapachol is a natural phenolic compound isolated from the bark of the lapacho tree. This tree is known botanically as Handroanthus impetiginosus, but was formerly known by various other botanical names such as Tabebuia avellanedae. Lapachol is also found in other species of Handroanthus.

Lapachol is usually encountered as a yellow, skin-irritating powder from wood. Chemically, it is a derivative of vitamin K.

Once studied as a possible treatment for some types of cancer, the levels of lapachol required for cancer treatment are considered too toxic for use as an in vivo chemotherapy treatment.

In 2024, A clinical trial published in the Journal of Cosmetic Dermatology determined that lower concentrations of lapachol were safe and efficacious in Facial Redness Reduction.

References

References

  1. [http://www.rdchemicals.com/chemicals.php?mode=details&mol_id=7988] Lapochol at R&D Chemicals.
  2. "ChromaDex Incorporated General Product Information for LAPACHOL(RG)".
  3. Record, Samuel J.. "Lapachol" pages 17-19. In: ''Tropical Woods'' (1925).
  4. (2007). "Evolution of a Charismatic Neotropical Clade: Molecular Phylogeny of ''Tabebuia'' s.l., Crescentieae, and Allied Genera (Bignoniaceae)". Systematic Botany.
  5. Louis F.Fieser. ''The Scientific Method'' pages 163-191. Reinhold Publishing Corporation, New York, 1964
  6. (2002). "Fetal growth in rats treated with lapachol". Contraception.
  7. Oral toxicology studies with lapachol. Morrison, Robert K.; Brown, Donald Emerson; Oleson, Jerome J.; Cooney, David A. [[Toxicology and Applied Pharmacology]] (1970), 17(1), 1-11.
  8. (2001). "Toxicology of Lapachol in rats: embryolethality". Brazilian Journal of Biology.
  9. (2007). "Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment". Phytotherapy Research.
  10. (2024). "The Clinical Efficacy of Lapachol in Facial Redness Reduction". Journal of Cosmetic Dermatology.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

1,4-naphthoquinones hydroxynaphthoquinones plant-toxins terpeno-phenolic-compounds
Want to explore this topic further?

Ask Mako anything about Lapachol — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report