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LAE-32

Chemical compound

Chemical compound

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Lysergic acid ethylamide (LAE-32 or LAE) is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is reported to have some LSD-like effects but is weaker and shorter lasting, with an active dose reported to be between 0.5 and 1.4mg.

It was studied by the CIA as part of Project MKULTRA. Documents published by the CIA under the Freedom of Information Act suggest it causes "a schizophrenia-like condition" but it allows people with schizophrenia to remain indifferent to their disorder. The drug has also been studied in psychedelic-assisted psychotherapy.

LAE-32 was first described in the scientific literature by Albert Hofmann and colleagues by 1955. It is not a controlled substance in Canada as of 2025.

References

References

  1. (1994). "Structure-activity relationships of the classic hallucinogens and their analogs". NIDA Research Monograph.
  2. (1965). "D-Lysergic Acid Diethylamide (LSD): A Review of its Present Status". Clinical Pharmacology and Therapeutics.
  3. (2020). "Psychedelic treatment of functional neurological disorder: a systematic review". Therapeutic Advances in Psychopharmacology.
  4. (1955). "Amide der stereoisomeren Lysergsäuren und Dihydro-lysergsäuren. 38. Mitteilung über Mutterkornalkaloide". Helvetica Chimica Acta.
  5. "Controlled Drugs and Substances Act".
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carboxamides ethyl-compounds psychedelic-lysergamides
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