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L-2-hydroxycarboxylate dehydrogenase (NAD+)

Class of enzymes

Class of enzymes

FieldValue
NameL-2-hydroxycarboxylate dehydrogenase (NAD+)
EC_number1.1.1.337
CAS_number81210-65-3
imagePDB 1hye EBI.jpg

L-2-hydroxycarboxylate dehydrogenase (NAD+) (, (R)-sulfolactate:NAD+ oxidoreductase, L-sulfolactate dehydrogenase, (R)-sulfolactate dehydrogenase, L-2-hydroxyacid dehydrogenase (NAD+), ComC) is an enzyme with systematic name (2S)-2-hydroxycarboxylate:NAD+ oxidoreductase. This enzyme catalyses the following chemical reaction

: (2S)-2-hydroxycarboxylate + NAD+ \rightleftharpoons 2-oxocarboxylate + NADH + H+

The enzyme from the archaeon Methanocaldococcus jannaschii uses as a substrate multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate.

References

References

  1. (July 2000). "Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea". Journal of Bacteriology.
  2. (July 2001). "The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology.
  3. (April 2002). "Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics". Natural Product Reports.
  4. (March 2005). "Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA". Microbiology.
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