KIAA0895L

Gene

KIAA0895L is located at q22.1 on chromosome 16 of the human genome. Its genomic DNA consists of 8,379 base pairs. KIAA0895L is located between EXOC3L and E2F4 on the right, and NOL3 and HSF4 on the left. The promoter for KIAA0895L is located on chromosome 16 and spans 67217367-67218383bp.

KIAA0895L was first documented by the Mammalian Gene Collection Program Team in 2002. There are several patents on KIAA0895L, two of those being patent US 6943241 and patent EP1308459.

Species distribution

KIAA0895L orthologs can be found in all mammals. It is not found in plants, archaea, or fungi. KIAA0895L has a single paralog, known as KIAA0895.

The known orthologs of KIAA0895L are listed below:

• Chimpanzee – LOC741288
• Rhesus monkey – LOC696623
• Dog – LOC489765
• Horse – LOC100053028
• Giant panda – PANDA_006923
• Cow – LOC512420
• Norway rat – LOC688736
• Zebra finch – LOC100223241
• Chicken – LOC415660
• Mouse – LOC74356
• Opossum – LOC100019983
• Puffer fish – Unnamed
• Sea squirt – LOC100177006
• Platypus – LOC100078127
• Zebrafish – LOC562097
• Frog – LOC100135412
• Sea urchin – KIAA0895
• Ciliated protozoa – TTherm_01042050
• Plasmodium – PY05482
• Trichoplax adherens – TRIADDRAFT_62861
• Kordia – KAOT1_03617

Structure

KIAA0895L is composed of 471 amino acids (53.5kDa). A proline-rich region was also revealed at 14-65 amino acids. There is also an area of low complexity at 2913-2917 bp in the 3’ UTR region. There is a conserved domain of unknown function, known as DUF1704, located at 1390-2083 bp.

Predicted post translational modifications

The following is a list of predicted post translational modifications found for KIAA0895L. These are predicted in all mammalian orthologs in the public sequence database.

Interacting proteins

No proteins that interact with KIAA0895L or its homolog have yet been identified.

Tissue distribution

KIAA0895L is expressed in many tissues of the body such as brain, testis, mammary glands, bladder, and the eye.

Clinical significance

KIAA0895L has been shown to be up regulated in lymphoblastoid cells from males with autism that is caused by an expansion of a CGG repeat in the promoter region of the fragile X mental retardation 1 gene located at Xq27.3 as well as in cells with a 15q11-q13 mutation.

References

1. "Entrez Gene: KIAA0895-like".
2. (July 2025)
3. [https://www.ncbi.nlm.nih.gov/nuccore/51511732?report=genbank&from65767006&to=65775384&strand=true NCBI]
4. [https://www.ncbi.nlm.nih.gov/gene/ NCBI Entrez Gene]
5. [http://genome.ucsc.edu/ UCSC Genome Bioinformatics]
6. "Genomatix".
7. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A..
8. [https://blast.ncbi.nlm.nih.gov/Blast.cgi BLAST (Basic Local Alignment Search Tool)]
9. [http://www.genome.jp/dbget-bin/www_bget?hsa:653319 KEGG]
10. [http://www.genome.jp/dbget-bin/www_bget?hsa:653319 KEGG]
11. [http://workbench.sdsc.edu SDBC(San Diego Supercomputer Center Biology Workbench)]
12. (April 1992). "CLUSTAL V: improved software for multiple sequence alignment". Comput. Appl. Biosci..
13. (July 2025)
14. [http://www.genome.jp/kegg/ KEGG(Kyoto Encyclopedia of Genes and Genomes)]
15. "Dotlet(My Hits)".
16. (February 2000). "Dotlet: diagonal plots in a web browser". Bioinformatics.
17. [https://blast.ncbi.nlm.nih.gov/Blast.cgi BLAST(Basic Local Alignment Search Tool)]
18. [[Swiss Institute of Bioinformatics]], [[ExPASy]] [http://www.expasy.org/tools/#proteome] {{Webarchive. link. (2010-04-13)
19. [https://www.genecards.org Genecards]
20. NCBI GEO (National Center for Biotechnology Information Gene Expression Omnibus)[https://www.ncbi.nlm.nih.gov/geo/]
21. (July 2007). "Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways". Hum. Mol. Genet..