Juxtacrine signalling

Cell–cell signaling

In this type of signaling, specific membrane-bound ligands bind to a cell's membrane. A cell with the appropriate cell surface receptor or cell adhesion molecule can bind to it. Cell-cell signaling can be extrinsic and intrinsic to the cells. Intrinsic signaling indicates that cells connect more directly with the help of cadherins, ephrins, and Notch-Delta signaling pathway, thus, more intrinsically with the cell defined machinery. Juxtracrine signaling is considered an intrinsic cell-to-cell signaling as cells communicate through surface level proteins. External cell-cell signaling involves bringing out information in or out of the cell without any direct contact with cell structures, except the binding sites for the signaling molecules. Such cell-cell signaling is utilized by the paracrine and autocrine signaling.

Some of the cell signaling pathways that are involved in cell-to-cell communication include: Notch-Delta, FGF, Wnt, EGF, TGF-beta, Hedgehog, Hippo, Jun kinase, Nf-kB, and retinoic acid receptor. Of all these pathways, juxtracrine signaling utilizes Notch and Hippo the most as they involve a more direct cell-to-cell contact signaling.

Notch signaling pathway, notably involved in neural development. In the Notch signaling pathway for vertebrates and Drosophila, the receiving cell is told not to become neural through the binding of Delta and Notch. Within the eye of vertebrates, which cells become optic neurons and which become glial cells is regulated by Notch and its ligands.

Some cells, like ephrin-Eph, are only able to communicate through juxtacrine signaling. Eph ligands can only activate receptors when bound to a membrane. This is because a high density of the Eph ligand is necessary for the receptor to bind to it. Ephrin-Eph is used for axon guidance, angiogenesis, and epithelial and neuronal cell migration.

Communicating junctions

Two adjacent cells can construct communicating conduits between their intracellular compartments: gap junctions in animals and plasmodesmas in plants.

Gap junctions are made of connexins in vertebrates and innexins in invertebrates. Electrical synapses are electrically conductive gap junctions between neurons. Gap junctions are critical for cardiac myocytes; mice and humans deficient in a particular gap junction protein have severe heart development defects.

Plasmodesmas in plants are cytoplasmic strands that pass through cell walls and facilitate connections with adjacent cells. Plasmodesmas are highly dynamic in both strucutural modifications and biogenesis. They are able to organize cells in domains, serving as basic developmental units for plants, as well as mediate the intracellular movement of a variety of proteins and nucleic acids.

Cell–extracellular matrix signaling

The extracellular matrix is composed of glycoproteins (proteins and mucopolysaccharides (glycosaminoglycan)) produced by the organism's cells. They are secreted not only to build a supportive structure but also to provide critical information on the immediate environment to nearby cells. Indeed, the cells can themselves interact by contact with extracellular matrix molecules and as such, this can be considered an indirect cell / cell communication. Cellular differentiation involves a cell changing its phenotypical or functional type.

References

References

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