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JNJ-26990990

Experimental anticonvulsant drug

Experimental anticonvulsant drug

| Drugs.com =

| elimination_half-life =

JNJ-26990990 is a broad-spectrum anticonvulsant drug currently under development by Janssen Pharmaceutica as a second-generation follow-up to the marketed drug topiramate. It was designed to have the same anticonvulsant effects as topiramate, but without the side effects associated with topiramate's carbonic anhydrase inhibition.

JNJ-26990990 entered phase II clinical trials in October 2007.

Metabolites and radioactive isotope-labeled derivatives of JNJ-26990990 have also been prepared to support its development.

References

References

  1. (December 2009). "Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies". Journal of Medicinal Chemistry.
  2. "Preparation of benzo-fused heteroaryl sulfamide derivatives for the treatment of epilepsy and related disorders".
  3. (September 22, 2008). "JNJ 26990990 Johnson & Johnson developing anticonvulsant Johnson & Johnson preclinical data". R & D Focus Drug News.
  4. (2010). "Analogue-Based Drug Discovery II".
  5. (January 2013). "Expeditious syntheses of stable and radioactive isotope-labeled anticonvulsant agent, JNJ-26990990, and its metabolites". Journal of Labelled Compounds & Radiopharmaceuticals.
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