From Surf Wiki (app.surf) — the open knowledge base

Isovaleryl-CoA dehydrogenase

Class of enzymes

Field	Value
Name	isovaleryl-CoA dehydrogenase
EC_number	1.3.8.4
CAS_number	37274-61-6
GO_code	0008470
image	1ivh.jpg
width	270
caption	Isovaleryl-CoA dehydrogenase tetramer, Human

In enzymology, an isovaleryl-CoA dehydrogenase () is an enzyme that catalyzes the chemical reaction

:3-methylbutanoyl-CoA + acceptor \rightleftharpoons 3-methylbut-2-enoyl-CoA + reduced acceptor

Thus, the two substrates of this enzyme are 3-methylbutanoyl-CoA and acceptor, whereas its two products are 3-methylbut-2-enoyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-methylbutanoyl-CoA:acceptor oxidoreductase. Other names in common use include isovaleryl-coenzyme A dehydrogenase, isovaleroyl-coenzyme A dehydrogenase, and 3-methylbutanoyl-CoA:(acceptor) oxidoreductase. This enzyme participates in valine, leucine and isoleucine degradation. It employs one cofactor, FAD.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code . It was created by a group containing K.A.Tiffany, D.L.Roberts, M.Wang, R.Paschke, A.-W.A.Mohsen, J.Vockley, and J.J.P.Kim. The structure was released on May 20, 1998.

Leucine metabolism

References

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-1.3.8 flavoproteins enzymes-of-known-structure mitochondrial-proteins

Want to explore this topic further?

Ask Mako anything about Isovaleryl-CoA dehydrogenase — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report