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Isovaleramide

Isovaleric acid amide Isovaleric amide beta-Methylbutyramide

Isovaleramide is an organic compound with the formula (CH3)2CHCH2C(O)NH2. The amide derived from isovaleric acid, it is a colourless solid.

Occurrence and biological activity

Isovaleramide is a constituent of valerian root.

In humans, it acts as a mild anxiolytic at lower doses and as a mild sedative at higher dosages. Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant. It inhibits the liver alcohol dehydrogenases and has a reported of greater than 400 mg/kg when administered intraperitoneally in mice.

It is a positive allosteric modulator of the GABAA receptor, similarly to isovaleric acid.

References

References

  1. "Use of isovaleramide as a mild anxiolytic and sedative agent".
  2. (1975). "Dipropylacetic series. XII. Anticonvulsant branched aliphatic acids and alcohols". European Journal of Medicinal Chemistry.
  3. (2010). "[Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii]". Biomedica.
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carboxamides anticonvulsants anxiolytics hemiterpenes gaba-analogues gabaa-receptor-positive-allosteric-modulators sedatives
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