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Isoquercetin

Isoquercitrin Isoquercetin Trifoliin Isotrifolin Trifoliin A Isohyperoside Isotrifoliin Quercetin-3-glucoside Quercetin-3-O-glucoside Quercetin 3-O-β-D-glucopyranoside Isoquercetin, isoquercitrin or isotrifoliin is a flavonoid, a type of chemical compound. It is the 3-O-glucoside of quercetin. Isoquercitrin can be isolated from various plant species including Mangifera indica (mango) and Rheum nobile (the Noble rhubarb). It is also present in the leaves of Annona squamosa, Camellia sinensis (tea). and Vestia foetida

Spectral data

The lambda-max for isoquercetin is 254.8 and 352.6 nm.

Potential clinical uses

Isoquercetin is presently being investigated for prevention of thromboembolism in selected cancer patients and as an anti-fatigue agent in kidney cancer patients treated with sunitinib.

There is a single case report of its use in the successful treatment of prurigo nodularis, a difficult to treat pruritic eruption of the skin.{{cite journal| title = Use of Isoquercetin in the Treatment of Prurigo Nodularis |url=http://jddonline.com/articles/dermatology/S1545961617P1156X/1 |date=November 2017 | volume=16 | issue=11 | pages=1156–1158 |journal=Journal of Drugs in Dermatology |first1=Christine M. |last1=Pennesi |first2=John |last2=Neely |first3=Ames G. |last3=Marks Jr. |first4=S. |last4=Alison Basak|pmid=29141065 }}

However it belongs to the PAINS (Pan-assay interference compounds) categories of chemicals.

References

References

  1. "Isoquercetin". [[PubChem]].
  2. (2004). "Characterization of phenolic compounds in some Indian mango cultivars". International Journal of Food Sciences and Nutrition.
  3. Panda S, Kar A. (2007). "Antidiabetic and antioxidative effects of ''Annona squamosa'' leaves are possibly mediated through quercetin-3-O-glucoside". BioFactors.
  4. (2003). "Simultaneous determination of all polyphenols in vegetables, fruits, and teas". Journal of Agricultural and Food Chemistry.
  5. C. Brevis, M. Quezada, P. Bustamante, L. Carrasco, A. Ruiz, S. Donoso, Huevil (Vestia foetida) poisoning of cattle in Chile ''The Veterinary record'' 156(14):452-3 May 2005
  6. [https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/view?cdrid=763277 NCT02195232]
  7. [https://clinicaltrials.gov/ct2/show/study/NCT02446795#contacts NCT02446795]
  8. (2014). "Chemistry: Chemical con artists foil drug discovery". Nature.
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quercetin-glycosides flavonoid-glucosides
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