Isoproscaline

Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists isoproscaline's dose as 40 to 80mg orally and its duration as 10 to 16hours. The onset was described as slow and about 2hours and the descent very slow and gradual and starting at about 6 or 7hours. The effects of isoproscaline included enhanced emotions, desire to move and dance, feelings of energy flow and freedom in the body, feelings of ecstasy, euphoria, meaningfulness, mental rejuvenation, enhanced sociability and conversation, body load, queasiness, nausea, discomfort, insomnia, and slight next-day irritability. No visual changes or other sensory effects were mentioned. Shulgin described isoproscaline as a "completely fascinating phenethylamine".

Interactions

Pharmacology

Pharmacodynamics

Isoproscaline shows affinity for the serotonin 5-HT2 receptors and acts as an agonist of the serotonin 5-HT2A receptor.

Chemistry

Isoproscaline is in a class of compounds commonly known as phenethylamines, and the full chemical name is 2-(4-isopropoxy-3,5-dimethoxyphenyl)ethanamine.

Synthesis

The chemical synthesis of isoproscaline has been described.

Analogues

Analogues of isoproscaline include mescaline, escaline, proscaline, allylescaline, and methallylescaline, among others.

Society and culture

Legal status

Canada

Isoproscaline is not a controlled substance in Canada as of 2025.

United Kingdom

In the UK, its highly likely that this compound would be covered by the "phenylethylamine amendment" to the misuse of drugs act likely rendering it a Class A controlled drug.

United States

Isoproscaline is unscheduled in the United States; however, because of its close similarity in structure and effects to mescaline, possession and sale of isoproscaline may be subject to prosecution under the Federal Analog Act.

References

References

1. (February 1977). "Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues". J Med Chem.
2. {{CitePiHKAL [http://www.erowid.org/library/books_online/pihkal/pihkal092.shtml Isoproscaline entry]
3. (2021). "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines". Front Pharmacol.
4. "Controlled Drugs and Substances Act".
5. (January 2026). "Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026)". U.S. [[Department of Justice]]: [[Drug Enforcement Administration]] (DEA): Diversion Control Division.