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Intranodal palisaded myofibroblastoma

Field	Value
name	Intranodal palisaded myofibroblastoma
image	Intranodal palisaded myofibroblastoma - intermed mag.jpg
width	250px
caption	Micrograph of an intranodal palisaded myofibroblastoma. H&E stain.
field	Oncology

Intranodal palisaded myofibroblastoma (IPM) is a rare primary tumour of lymph nodes, that classically presents as an inguinal mass.

It afflicts predominantly males of middle age.

Signs and symptoms

IPMs present as painless lymphadenopathy. They usually are found in the inguinal region and grow slowly. The signs and symptoms are non-specific, i.e. it is not possible to diagnose an IPM from the symptoms and manner in which they present. The main (clinical) differential diagnosis of IPM is metastatic cancer, e.g. squamous cell carcinoma, melanoma, adenocarcinoma.

Diagnosis

IPMs are diagnosed by examination of the tissue by a pathologist. They have a rim of peripheral lymphoid tissue (remnant of a lymph node) and consist of spindle cells with nuclear palisading. Red blood cell extravasation is common and blood vessels surrounded by collagen with (fine) peripheral spokes (amianthoid fibers) are usually seen.

Immunostains for smooth muscle actin and cyclin D1 are characteristically positive. The main histologic differential diagnosis is schwannoma. Image: Intranodal palisaded myofibroblastoma - low mag.jpg | Low mag. Image: Intranodal palisaded myofibroblastoma - high mag.jpg | High mag.

Treatment

Simple surgical excision is considered curative. Rare recurrences have been reported.

References

(Feb 2007). "Intranodal palisaded myofibroblastoma.". Arch Pathol Lab Med.
(Sep 1991). "Selective location of palisaded myofibroblastoma with amianthoid fibres.". J Clin Pathol.
(May 1999). "Recurrent intranodal palisaded myofibroblastoma with metaplastic bone formation.". Arch Pathol Lab Med.

Info: Wikipedia Source

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diseases-of-veins,-lymphatic-vessels-and-lymph-nodes

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