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Hypoxanthine

Hypoxanthine is a naturally occurring purine derivative. It is occasionally found as a constituent of nucleic acids, where it is present in the anticodon of tRNA in the form of its nucleoside inosine. It has a tautomer known as 6-hydroxypurine. Hypoxanthine is a necessary additive in certain cells, bacteria, and parasite cultures as a substrate and nitrogen source. For example,{{cite web |title=Estimation of Plasmodium falciparum drug susceptibility by the 3H-hypoxanthine uptake inhibition assay

In August 2011, a report, based on NASA studies with meteorites found on Earth, was published suggesting hypoxanthine and related organic molecules, including the bases of the DNA and RNA components adenine and guanine, which were found in trace amounts in meteorites, may have been formed by reactions occurring extraterrestrially in outer space.

The Pheretima aspergillum worm, used in Chinese medicine preparations, contains hypoxanthine.

Reactions

It is one of the products of the action of xanthine oxidase on xanthine. However, more frequently in purine degradation, xanthine is formed from oxidation of hypoxanthine by xanthine oxidoreductase.

Hypoxanthine-guanine phosphoribosyltransferase converts hypoxanthine into IMP in nucleotide salvage.

Hypoxanthine is also a spontaneous deamination product of adenine. Because of its resemblance to guanine, the spontaneous deamination of adenine can lead to an error in DNA transcription/replication, as it base pairs with cytosine. Hypoxanthine is removed from DNA by base excision repair, initiated by N-methylpurine glycosylase (MPG), also known as alkyl adenine glycosylase (Aag).

Additional images

Image:Adenin.svg|Adenine Image:Guanin.svg|Guanine Image:Xanthin.svg|Xanthine

References

References

  1. (September 2000). "Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine". Transactions of the Royal Society of Tropical Medicine and Hygiene.
  2. (11 August 2011). "Carbonaceous meteorites contain a wide range of extraterrestrial nucleobases". [[Proceedings of the National Academy of Sciences of the United States of America]].
  3. Steigerwald, John. (8 August 2011). "NASA Researchers: DNA Building Blocks Can Be Made in Space". [[NASA]].
  4. ScienceDaily Staff. (9 August 2011). "DNA Building Blocks Can Be Made in Space, NASA Evidence Suggests".
  5. The Pharmacology of Chinese Herbs, Second Edition By Kee C. Huang
  6. (2009). "Recognition and Processing of a New Repertoire of DNA Substrates by Human 3-Methyladenine DNA Glycosylase (AAG)". Biochemistry.
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purines nucleobases
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