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Hydrophilization

Hydrophilization is a process used on hydrophobic drugs to increase their release rate from capsules, which depends on the rate of dissolution, by covering the surfaces of their particles with minute droplets of a dissolved hydrophilic polymer (such as methyl cellulose or hydroxyethyl cellulose). In tablet or capsule formulations, this enhances the dissolution and disintegration of the drug.

References

References

  1. (November 2020). "Hydroxypropyl Methylcellulose E15: A Hydrophilic Polymer for Fabrication of Orodispersible Film Using Syringe Extrusion 3D Printer". Polymers.
  2. (July 1978). "Effect of hydrophilization of hydrophobic drugs on release rate from capsules". Journal of Pharmaceutical Sciences.
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