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HULC (gene)
In molecular biology, Highly Up-regulated in Liver Cancer (non-protein coding), also known as HULC, is a long non-coding RNA. It was first identified in hepatocellular carcinoma, and is also expressed in colorectal carcinomas that metastasise to the liver. It may have a role in the post-transcriptional regulation of gene expression. It downregulates the expression of several microRNAs, including miR-372. Expression of HULC is upregulated by CREB, there is a CREB-binding site in the promoter of HULC. miR-372 represses translation of the kinase PRKACB, so downregulation of miR-372 leads to increased levels of PRKACB. PRKACB activates CREB by phosphorylation, therefore leading to increased expression of HULC.
References
References
- (Jan 2007). "Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA". Gastroenterology.
- (Jun 2009). "Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis". European Journal of Gastroenterology & Hepatology.
- (Sep 2010). "CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer". Nucleic Acids Research.
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