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Homing (hematopoietic)

Migration of cells toward their organ of origin

Migration of cells toward their organ of origin

Homing is the phenomenon whereby cells migrate to the organ of their origin. By homing, transplanted hematopoietic cells are able to travel to and engraft (establish residence) in the bone marrow. Various chemokines and receptors are involved in the homing of hematopoietic stem cells.

Sites

  • Bone marrow
  • Lymph nodes
  • Skin

References

References

  1. Cyster, JG. (1999). "Chemokines and B-cell homing to follicles".
  2. (23 April 2004). "Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination". Journal of Leukocyte Biology.
  3. Yusuf, Rushdia Z.. (17 March 2009). "Homing of Hematopoietic Cells to the Bone Marrow". Journal of Visualized Experiments.
  4. von Andrian, Ulrich H.. (1 November 2003). "Homing and cellular traffic in lymph nodes". Nature Reviews Immunology.
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This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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