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HIST1H4E

Protein-coding gene in the species Homo sapiens

Protein-coding gene in the species Homo sapiens

Histone H4 is a protein that in humans is encoded by the HIST1H4E gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

References

References

  1. (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics.
  2. (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics.
  3. "Entrez Gene: HIST1H4E histone cluster 1, H4e".
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human-proteins
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