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Hepatoprotection

Ability of a chemical substance to prevent liver damage


Ability of a chemical substance to prevent liver damage

Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. This is opposite to hepatotoxicity.

Hepatoprotective molecules used in emergency medicine

  • Acetylcysteine is considered the hepatoprotective drug of choice when treating an overdose of acetaminophen/paracetamol.
  • Silymarin is given intravenously to treat poisoning from Amanita mushrooms according to the Santa Cruz protocol devised by Dr Todd Mitchell at UCSC.

Herbs with potentially hepatoprotective constituents

  • Astragalus membranaceus

  • Brassica

  • Silybum marianum, from which silymarin is derived

  • Andrographis paniculata

References

References

  1. "Archived copy".
  2. (Jan 2011). "Biological analysis of herbal medicines used for the treatment of liver diseases.". Biomedical Chromatography.
  3. (Sep 1, 2001). "Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens.". Mutation Research.
  4. Andrographis paniculata http://www.stuartxchange.com/Sinta.html
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