Surf Wiki
Save to docs
general/life-extension

From Surf Wiki (app.surf) — the open knowledge base

Heavy isotope diet

Isotopic food

Isotopic food

Heavy isotope diet is the consumption of nutrients in which some atoms are replaced with their heavier non-radioactive isotopes, such as deuterium (2H) or heavy carbon (13C). Biomolecules that incorporate heavier isotopes give rise to more stable molecular structures under certain circumstances, which is hypothesized to increase resistance to damage associated with ageing or diseases.

Medicines with some hydrogen atoms substituted with deuterium are called deuterated drugs, while substances that are essential nutrients can be used as food constituents, making this food "isotopic". Consumed with food, these nutrients become building material for the body. The examples are deuterated polyunsaturated fatty acids, essential aminoacids, DNA bases such as cytosine, or heavy water and glucose.

Suggested mechanism

One of the most pernicious and irreparable types of oxidative damage inflicted by reactive oxygen species (ROS) upon biomolecules involves the carbon-hydrogen bond cleavage (hydrogen abstraction). Intriguingly, the biomolecules most damageable by this type of damage belong to the group of essential nutrients (10 out of 20 amino acids; nucleosides at certain conditions (conditionally essential); all polyunsaturated fatty acids). In theory, replacing hydrogen with deuterium "reinforces" the bond due to the kinetic isotope effect, and such reinforced biomolecules taken up by the body will be more resistant to ROS.

Deuterated omega-6 fatty acids for humans with degenerative diseases

The company Retrotope pioneered the development a source of deuterated omega-6 fatty acid di-deuterated linoleic acid ethyl ester (RT001) as a food additive for potential treatment of neurodegenerative diseases such as Friedreich’s ataxia and infantile neuroaxonal dystrophy. FDA has granted it an orphan drug designation and it passed the Phase I/II clinical trials (as of 2018).

References

References

  1. "Heavy hydrogen keeps yeast looking good".
  2. (2017). "Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first". Atherosclerosis.
  3. (2020). "Deuterium diet". Chemistry & Industry.
  4. (2017). "A strong developmental isotope effect in Caenorhabditis elegans induced by 5,5-deuterated lysine". Amino Acids.
  5. (2016). "Rational Manipulation of DNA Methylation by Using Isotopically Reinforced Cytosine". ChemBioChem.
  6. (2016). "Yeast longevity promoted by reversing aging-associated decline in heavy isotope content". npj Aging and Mechanisms of Disease.
  7. (2007). "Reactive Oxygen Species, Isotope Effect, Essential Nutrients, and Enhanced Longevity". Rejuvenation Research.
  8. (2017). "First deuterated drug approved". Nature Biotechnology.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

life-extension nutrients hypotheses
Want to explore this topic further?

Ask Mako anything about Heavy isotope diet — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report