Surf Wiki
Save to docs
general/proteases

From Surf Wiki (app.surf) — the open knowledge base

Gingipain

Protein family

Protein family

Gingipains are a family of proteases secreted by Porphyromonas gingivalis. Among other functions, it works to degrade cytokines, thereby downregulating the host response in the form of reduced inflammation. Gingipain has been studied for its potential role in the development of Alzheimer's disease.

References

References

  1. Stathopoulou, PG. Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. ''J Clin Perio'' 2010;37:24–29
  2. [https://www.science.org/doi/10.1126/sciadv.aau3333 Dominy, S.S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C. and Holsinger, L.J., 2019. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Science Advances, 5(1), p.eaau3333.]
  3. [https://www.newscientist.com/article/2191814-we-may-finally-know-what-causes-alzheimers-and-how-to-stop-it/ ''New Scientist'' 29 January 2019]
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

proteases ec-3.4
Want to explore this topic further?

Ask Mako anything about Gingipain — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report