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Geranylgeraniol

Geranylgeraniol is a diterpenoid alcohol. It is a colorless waxy solid.{{cite journal |doi=10.15227/orgsyn.084.0043|title=Stereoselective Isoprenoid Chain Extension with Acetoacetate Dianion: (E, E, E)-Geranylgeraniol from (E, E)-Farnesol|journal=Organic Syntheses|year=2007|volume=84|page=43|first1=Yinghua|last1=Jin|first2=Frank G.|last2=Roberts|first3=Robert M.|last3= Coates

Geranylgeraniol is synthesized in humans through the mevalonate pathway.

As its pyrophosphate, it is also used in the [post-translational modification by the process called geranylgeranylation.

Geranylgeraniol is a potent inhibitor of Mycobacterium tuberculosis in vitro.

References

(2006). "Kirk-Othmer Encyclopedia of Chemical Technology".
(2000-11-21). "Isoprenoid biosynthesis: The evolution of two ancient and distinct pathways across genomes". Proceedings of the National Academy of Sciences.
(2004-04-01). "Isoprenoids: Remarkable diversity of form and function". Lipids.
(2007). "Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro". Planta Medica.

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diterpenes fatty-alcohols

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