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Geldanamycin

| NFPA-H = | NFPA-F = | NFPA-R = | NFPA-S = Geldanamycin is a 1,4-benzoquinone ansamycin antitumor antibiotic that inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein.{{Cite journal | doi-broken-date = 12 July 2025

| doi-access = free

Biosynthesis

Geldanamycin was originally discovered in the organism Streptomyces hygroscopicus.{{Cite journal

Notes

References

{{Cite journal | doi-access = free

References

(2011). "Molecular Chaperones".
(2013). "Geldanamycin-Induced Phosphatidylserine Translocation in the Erythrocyte Membrane". Cell Physiol Biochem.

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1,4-benzoquinones carbamates lactams phenol-ethers ethers secondary-alcohols ansamycins

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