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Gadd7

Non-coding RNA

Field	Value
Name	gadd7
image	gadd7_ss.png
width	300px
caption	Conserved secondary structure of gadd7 RNA
Symbol	gadd7
Rfam	RF01800
RNA_type	Gene
Tax_domain	Cricetulus

gadd7 (growth arrested DNA-damage inducible gene 7) is a non-coding RNA discovered in the ovaries of the chinese hamster (Cricetulus griseus). Homologs have been identified in the closely related Long-tailed Dwarf Hamster (C. longicaudatus). Although the gene for this RNA contains open reading frames, translation studies found no protein product hence gadd7 has been classified as non-coding RNA.

gadd7 was previously characterised as a hydrogen peroxide-inducible transcript but has more recently been linked with lipotoxicity - where the accumulation of lipids in non-adipose tissue brings about cell death. gadd7 appears to be a key element in the lipotoxicty pathway, when it is knocked out the resulting mutant is much more resistant to oxidative stress.

The proposed mechanism for gadd7's role in lipotoxicity is:

The lipid palmitate builds to high concentration within a cell
Reactive oxygen species (ROS) are generated
This stress induces the expression of gadd7
A feed-forward mechanism occurs
ER stress brings about death of the cell

References

(March 2009). "The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress". J. Biol. Chem..
(May 1996). "A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein product". Nucleic Acids Res..
(January 1996). "Hydrogen peroxide induces the expression of adapt15, a novel RNA associated with polysomes in hamster HA-1 cells". Arch. Biochem. Biophys..
Unger RH. (2002). "Lipotoxic diseases". Annu. Rev. Med..

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

non-coding-rna

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