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FMR1-AS1 gene
Non-coding RNA in the species Homo sapiens
Non-coding RNA in the species Homo sapiens
In molecular biology, FMR1 antisense RNA 1 (FMR1-AS1), also known as ASFMR1 or FMR4, is a long non-coding RNA. The FMR1-AS1 gene overlaps, and is antisense to, the CGG repeat region of the FMR1 gene. Its expression is upregulated in fragile X syndrome premutation carriers, and silenced in patients with fragile X syndrome. FMR1-AS1 has an anti-apoptotic function.
References
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References
- (2007). "An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.". Hum Mol Genet.
- (2008). "A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome.". PLOS ONE.
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