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Flunisolide

Chemical compound

Field	Value
Verifiedfields	changed
verifiedrevid	461101454
IUPAC_name	(1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
image	Flunisolide.png
image_class	skin-invert-image
image2	Flunisolide ball-and-stick.png
image_class2	bg-transparent
tradename	Aerobid, Nasalide, Nasarel, others
Drugs.com
MedlinePlus	a681048
routes_of_administration	Inhaled
protein_bound	40% after inhalation
elimination_half-life	1.8 hours
IUPHAR_ligand	7076
CAS_number_Ref
CAS_number	3385-03-3
ATC_prefix	R01
ATC_suffix	AD04
ATC_supplemental
PubChem	82153
DrugBank_Ref
DrugBank	DB00180
ChemSpiderID_Ref
ChemSpiderID	74144
UNII_Ref
UNII	78M02AA8KF
KEGG_Ref
KEGG	D00324
ChEBI_Ref
ChEBI	5106
ChEMBL_Ref
ChEMBL	1512
C	24	H=31	F=1	O=6
smiles	O=C\1\C=C/[C@]2(/C(=C/1)C@@HC[C@H]3[C@H]4C@([C@@]5(OC(O[C@@H]5C4)(C)C)C(=O)CO)C)C
StdInChI_Ref
StdInChI	1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
StdInChIKey_Ref
StdInChIKey	XSFJVAJPIHIPKU-XWCQMRHXSA-N
synonyms	6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione acetone cyclic 16,17-acetal

| Drugs.com = | elimination_half-life = 1.8 hours Flunisolide (marketed as AeroBid among others) is a corticosteroid often prescribed as a treatment for allergic rhinitis. Intranasal corticosteroids are the most effective medication for controlling symptoms.

Flunisolide's principal mechanism of action is to activate glucocorticoid receptors, indicating an anti-inflammatory action. The effects of topical corticosteroids are not immediate and must be used for at least a few days for noticeable relief. As-needed use is less effective than regular recommended use. Flunisolide should not be used for nasal infections. It should not be continued if symptoms are not relieved after regular use for over two to three weeks.

Patented in 1958 and approved for medical use in 1978, it is on the World Health Organization's List of Essential Medicines.

Side effects

Temporary nose and throat dryness, irritation, bleeding, or unpleasant taste or smell may occur. Nasal septum perforation has been rarely reported. Rare but localized infections of the nose and pharynx with Candida albicans have also been reported. Its long-term use may raise the chances of cataracts or glaucoma.

Flunisolide nasal spray is absorbed into the circulatory system (blood). Corticosteroid nasal sprays may affect the hypothalamic-pituitary-adrenal axis function in humans. After obtaining the desired clinical effect, the maintenance dose should be reduced to the smallest amount required to control the symptoms. The amount can be as low as one spray in each nostril daily. Utilizing the minimum effective dose reduces possibility of side effects. Recommended amounts of intranasal corticosteroids are generally not associated with systemic side effects.

Corticosteroids inhibit wound healing, so corticosteroid nasal sprays should be used cautiously in patients who have experienced recent nasal septal ulcers, recurrent epistaxis, nasal surgery or trauma, until healing. In pregnancy, recommended doses of intranasal corticosteroids are safe and effective.

References

"Flunisolide". DrugBank.
(August 2008). "The diagnosis and management of rhinitis: an updated practice parameter". The Journal of Allergy and Clinical Immunology.
"Flunisolide Nasal Solution". U.S. National Library of Medicine.
(2006). "Analogue-based Drug Discovery". John Wiley & Sons.
(2021). "World Health Organization model list of essential medicines: 22nd list (2021)". World Health Organization.
"FLUNISOLIDE - NASAL (Nasalide, Nasarel) side effects, medical uses, and drug interactions". MedicineNet.
"Nasalide (Flunisolide (Nasal Spray)) Drug Information: Clinical Pharmacology - Prescribing Information". RxList.

Info: Wikipedia Source

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acetonides corticosteroid-cyclic-ketals diketones diols organofluorides glucocorticoids

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