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Firocoxib

COX-2 selective NSAID veterinary drug

COX-2 selective NSAID veterinary drug

FieldValue
Verifiedfieldschanged
verifiedrevid443742691
imageFirocoxib.svg
image_classskin-invert-image
image2Firocoxib-3D-spacefill.png
image_class2bg-transparent
alt2Firocoxib molecule
tradenameEquioxx, Previcox
Drugs.com{{ubl
DailyMedIDFirocoxib
pregnancy_AU
routes_of_administrationBy mouth
ATCvetyes
ATC_prefixM01
ATC_suffixAH90
legal_AUS4
legal_BR
legal_CARx-only
legal_CA_comment
legal_DE
legal_NZ
legal_UKPOM
legal_USRx-only
legal_US_comment
legal_EURx-only
legal_EU_comment
legal_UN
CAS_number_Ref
CAS_number189954-96-9
PubChem208910
DrugBank_Ref
DrugBankDB09217
ChemSpiderID_Ref
ChemSpiderID181008
UNII_Ref
UNIIY6V2W4S4WT
KEGG_Ref
KEGGD03712
ChEBI_Ref
ChEBI76136
ChEMBL_Ref
ChEMBL69998
IUPAC_name3-(Cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
C17H=20O=5S=1
SMILESO=C2OC(C(=C2\OCC1CC1)\c3ccc(cc3)S(=O)(=O)C)(C)C
StdInChI_Ref
StdInChI1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
StdInChIKey_Ref
StdInChIKeyFULAPETWGIGNMT-UHFFFAOYSA-N

| Drugs.com = {{ubl | |

| elimination_half-life =

Firocoxib, sold under the brand names Equioxx and Previcox among others, is a nonsteroidal anti-inflammatory drug of the COX-2 inhibitor (coxib) class, approved for use in horses (Equioxx) and for use in dogs (Previcox). Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine.

Firocoxib, manufactured by Merial, was approved for veterinary use in the United States for dogs in July 2004, and for horses in July 2007, as an oral paste (Equioxx) and July 2016, as tablets.

Firocoxib is also available as a generic medication for horses and for dogs.

References

References

  1. (22 October 2009). "Product information".
  2. (14 July 2020). "Equioxx- firocoxib tablet, chewable".
  3. (24 February 2022). "Equioxx- firocoxib paste".
  4. (23 July 2020). "Previcox- firocoxib tablet, chewable".
  5. (30 June 2008). "Equioxx EPAR".
  6. (16 March 2007). "Previcox EPAR".
  7. (17 June 2022). "Coxatab EPAR".
  8. (15 September 2004). "Previcox PI".
  9. (June 2019). "Pharmacological Regulation in the USA and Pharmacokinetics Parameters of Firocoxib, a Highly Selective Cox-2, by Pain Management in Horses". Journal of Equine Veterinary Science.
  10. (2 July 2007). "New NSAID Equioxx (firocoxib) Approved by USEF". The Horse.
  11. [http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/veterinary/000142/WC500065936.pdf Equioxx] {{Webarchive. link. (21 December 2014 , [[European Medicines Agency]] (EMA))
  12. (1 July 2007). "Merial launches first firocoxib for horses".
  13. (1 August 2022). "FDA Approves the First Generic Firocoxib Tablets for Horses".
  14. (7 June 2022). "FDA Approves the First Generic Firocoxib Tablets for Dogs".
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

4-(methylsulphonyl)phenyl-compounds dog-medications equine-medications furanones cyclooxygenase-2-inhibitors nonsteroidal-anti-inflammatory-drugs ethers cyclopropyl-compounds
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