Surf Wiki
Save to docs
general/synthetic-opioids

From Surf Wiki (app.surf) — the open knowledge base

Ethoheptazine

Opioid analgesic drug

Opioid analgesic drug

| elimination_half-life =

Ethoheptazine (trade name Zactane) is an opioid analgesic from the phenazepane family. It was invented in the 1950s and is a ring expanded analogue of pethidine.

Ethoheptazine produces similar effects to other opioids, including analgesia, sedation, dizziness, and nausea. It was sold by itself as Zactane, and is still available as a combination product with acetylsalicylic acid and meprobamate as Equagesic, which is used for the treatment of conditions where both pain and anxiety are present. It was also investigated for use as an antitussive.

It is no longer prescribed, as it is no longer FDA approved, and not available for United States' Pharmacy Processing. Revocation of FDA Approved Medications Status stems from a combination of efficacy vs. toxicity, and the more-varied and historically safer benzodiazepines class. Only reversal of the FDA's decision, allows removing the drug from the CSD. Ethoheptazine is not listed as a controlled substance under the Controlled Substances Act, 1970 in the United States. The controlled status (Schedule IV) of Equagesic was due to the meprobamate content. Regulation elsewhere varies.

References

References

  1. "Procedure for the preparation of a new derivative of pirazolidine-hexametilenimina with therapeutic properties.".
  2. (October 1957). "Analgesic effectiveness of orally administered ethoheptazine in man". The American Journal of the Medical Sciences.
  3. (January 1964). "Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine).". Journal of Medicinal Chemistry.
  4. (March 1962). "[Current pharmaco-therapeutic possibilities in the treatment of pain. Experiments with ethoeptazine]". Minerva Medica.
  5. (September 1974). "Treatment of musculoskeletal pain and associated anxiety with an ethoheptazine-aspirin-meprobamate combination (equagesic): a controlled study". Current Therapeutic Research, Clinical and Experimental.
  6. (November 1979). "Investigation of narcotics and antitussives using drug discrimination techniques". The Journal of Pharmacology and Experimental Therapeutics.
  7. PDR 1978, pp 1618
  8. "Conversion Factors for Controlled Substances". Drug Enforcement Agency, U.S. Department of Justice.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

synthetic-opioids azepanes ethyl-esters mu-opioid-receptor-agonists
Want to explore this topic further?

Ask Mako anything about Ethoheptazine — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report