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Ethacridine lactate

Pair of enantiomers

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Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an antiseptic in solutions of 0.1%. It is effective against mostly Gram-positive bacteria, such as Streptococci and Staphylococci, but ineffective against Gram-negative bacteria such as Pseudomonas aeruginosa.

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used.{{Cite journal

References

Merck Index, 11th Ed., 3668
(1989). "[Antiseptic sensitivity of clinical strains of Pseudomonas aeruginosa]". Antibiotiki i Khimioterapiia.

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antiseptics lactates acridines phenol-ethers aromatic-amines ethoxy-compounds

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