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Enoyl-acyl carrier protein reductase

InterPro Family

Field	Value
Name	Enoyl-acyl carrier protein reductase
EC_number	1.3.1.9
CAS_number	37251-08-4
GO_code	0016631
image	5cp8.jpg
width	270
caption	Enoyl-[acyl-carrier-protein] reductase [NADH] tetramer, Mycobacterium tuberculosis

Enoyl-acyl carrier protein reductase (ENR or FabI) (), is a key enzyme of the type II fatty acid synthesis (FAS) system. ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes.

:[[Image:FattyAcid-MB-Reduction2.svg|400px]]

At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria Streptococcus pneumoniae.

References

(August 2004). "Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum". The Biochemical Journal.
(May 2004). "Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase". Antimicrobial Agents and Chemotherapy.
(December 2006). "Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae". The Journal of Antibiotics.

Info: Wikipedia Source

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ec-1.3.1

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